Multiple Sclerosis and Malabsorption

Gupta, Jagdish K.; Ingegno, Alfred P.; Cook, Albert W.; Pertschuk, Louis P.
December 1977
American Journal of Gastroenterology;Dec1977, Vol. 68 Issue 6, p560
Academic Journal
Malabsorption tests were studied in 52 patients with multiple sclerosis. The stools were examined microscopically for fat and undigested meat fibers and were found to be abnormal in 41.6 and 40.9% respectively. Abnormally low five hour excretion of d-xylose was demonstrated in 26.6% cases. Malabsorption of Vitamin B12 was found in 11.9% cases. The jejunal mucosa was examined histologically and by tissue immune technic including viral studies. Histology showed normal mucosa in all except seven patients in whom an increased inflammatory infiltrate was present. Fluorescent antibody studies revealed the presence of measles virus antigen in all patients and immunofluorescent studies showed a variable degree of immune reaction in the majority of cases. The significance of these findings in the pathogenesis of multiple sclerosis is discussed.


Related Articles

  • Gluten sensitivity and neuromyelitis optica: two case reports. Jacob, S.; Zarei, M.; Kenton, A.; Allroggen, H. // Journal of Neurology, Neurosurgery & Psychiatry;Jul2005, Vol. 76 Issue 7, p1028 

    Neuromyelitis optica is a clinical syndrome characterised by acute transverse myelitis plus an acute or subacute optic neuritis with or without recovery. Although once believed to be a variant of multiple sclerosis, diagnostic criteria have recently been proposed for neuromyelitis optica, making...

  • Cost-effective strategy for the serological investigation of coeliac disease. Bowron, A.; Moorghen, M.; Morgan, J. E.; Osborne, J. R.; Stansbie, D.; Stone, J. E. // Annals of Clinical Biochemistry;Jul2000, Vol. 37 Issue 4, p467 

    Increased numbers of requests for serological investigation of coeliac disease, and a local trend to request both anti-gliadin antibodies (AGA) and antiendomysium antibodies (AEA) simultaneously, resulted in cost pressures that prompted a review of our practice. Serology results from all...

  • Virus Demyelination. Fazakerley, John K.; Walker, Robert // Journal of NeuroVirology;Apr2003, Vol. 9 Issue 2, p148 

    A number of viruses can initiate central nervous system (CNS) diseases that include demyelination as a major feature of neuropathology. In humans, the most prominent demyelinating diseases are progressive multifocal leukoencephalopathy, caused by JC papovirus destruction of oligodendrocytes, and...

  • Human endogenous retrovirus-K18 Env as a risk factor in multiple sclerosis. Tai, A. K.; O'Reilly, E. J.; Alroy, K. A.; Simon, K. C.; Munger, K. L.; Huber, B. T.; Ascherio, A. // Multiple Sclerosis (13524585);Nov2008, Vol. 14 Issue 9, p1175 

    Background The human endogenous retrovirus (HERV)-K18 Env is in Epstein-Barr virus (EBV)-associated superantigen. Given the evidence for a role of EBV in the etiology of multiple sclerosis (MS), HERV-K18 Env is a plausible candidate for association with MS. Objective To assess whether variation...

  • The Role of Myelin in Theiler's Virus Persistence in the Central Nervous System. Roussarie, Jean-Pierre; Ruffi�, Claude; Brahic, Michel // PLoS Pathogens;Feb2007, Vol. 3 Issue 2, p212 

    Theiler's virus, a picornavirus, persists for life in the central nervous system of mouse and causes a demyelinating disease that is a model for multiple sclerosis. The virus infects neurons first but persists in white matter glial cells, mainly oligodendrocytes and macrophages. The mechanism,...

  • High prevalence of autoantibodies against phosphoglycerate mutase 1 in patients with autoimmune central nervous system diseas. Kimura, A.; Sakurai, T.; Koumura, A. // Current Medical Literature: Multiple Sclerosis;2010, Vol. 2 Issue 2, p47 

    In this article, the author discusses the study on the dominance of autoantibodies over phosphoglycerate mutase 1 in patients with autoimmune central nervous system disorder. The author states that the possible target antigens of an autoimmune response in multiple sclerosis (MS) remained...

  • DC-SIGN and CD150 Have Distinct Roles in Transmission of Measles Virus from Dendritic Cells to T-Lymphocytes. de Witte, Lot; de Vries, Rory D.; van der Vlist, Michiel; Yüksel, Selma; Litjens, Manja; de Swart, Rik L.; Geijtenbeek, Teunis B. H. // PLoS Pathogens;Apr2008, Vol. 4 Issue 4, p1 

    Measles virus (MV) is among the most infectious viruses that affect humans and is transmitted via the respiratory route. In macaques, MV primarily infects lymphocytes and dendritic cells (DCs). Little is known about the initial target cell for MV infection. Since DCs bridge the peripheral...

  • Porcine circovirus type 2 (PCV2) antigen localisation and post-weaning multisystemic wasting syndrome (PMWS) in free-ranging wild boar ( Sus scrofa ssp scrofa) in Italy. Morandi, Federico; Verin, Ranieri; Sarli, Giuseppe; Canetti, Nicola; Scacco, Marianne; Panarese, Serena; Poli, Alessandro // European Journal of Wildlife Research;Oct2010, Vol. 56 Issue 5, p717 

    Wild boar ( Sus scrofa ssp scrofa) is a host of porcine circovirus 2 (PCV-2), and infection in this species has been reported in many countries. This study sampled tissues from 348 wild boars in Italy in the provinces of Bologna, Padua and Pisa. No clinical signs or macroscopic lesions were...

  • Role of reverse transcriptase polymerase chain reaction for the diagnosis of human rabies. Biswal, Manisha; Ratho, Radha Kanta; Mishra, Baijayantimala // Indian Journal of Medical Research;Jun2012, Vol. 135 Issue 6, p837 

    Background & objectives: Traditionally, rabies diagnosis is made by demonstration of rabies viral antigen by direct immunofluorescence (DIF) and mouse inoculation test (MIT). The present study was carried out to evaluate the role of reverse transcriptase-polymerase chain reaction (RT-PCR) in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics