TITLE

Effect of Antrectomy and Vagisecretion on Gastric Acid Output and Gastrin Secretion

AUTHOR(S)
Ashby, David B.; Himal, Harry S.
PUB. DATE
December 1977
SOURCE
American Journal of Gastroenterology;Dec1977, Vol. 68 Issue 6, p556
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In three dogs with denervated Heidenhain pouches, ingestion of cooked beef liver caused increased acid output and gastrin secretion. After antrectomy and gastrojejunal anastomosis, ingestion of the liver did not increase serum gastrin levels throughout the experiment. Acid output, however, although markedly reduced, was elevated over basal levels during the last three hours of the four-hour experiment. Total abdominal vagotomy did not alter gastrin secretion but further inhibited acid output in response to the test meal. These results indicate that in the dog intestinal gastrin is not released in response to a beef liver meal. Acid output postantrectomy, although reduced, does respond to the meal and is further decreased after vagotomy. A hormonal mechanism other than the release of intestinal gastrin is responsible for the intestinal phase of gastric acid secretion.
ACCESSION #
16144906

 

Related Articles

  • THE INHIBITORY INFLUENCE OF THE PYLORIC ANTRUM ON GASTRIC SECRETION IN DOGS. Hunt, D.R.; Forrest, A.P.M. // Australian Journal of Experimental Biology & Medical Science;Feb1976, Vol. 54 Issue 1, p79 

    Examines the effect of denervation of the pyloric antrum and of subsequent vagotomy on the secretory responses of an innervated or a denervated gastric pouch in the dog to histamine and pentagastrin. Sensitivity of the gastric pouch to stimulation; Concept that an inhibitory reflex is concerned...

  • Comparison of the Effect of Different Forms of a Protein Test Meal on Gastric Acid and Gastrin Secretion. Ashby, D. B.; Himal, H. S. // American Journal of Gastroenterology;Apr1975, Vol. 63 Issue 4, p321 

    In three mongrel dogs with fundic pouches, the effect of a chopped versus a blenderized test meal on gastric acid output and gastrin secretion was investigated. The blenderized test meal caused a greater increase in acid output and gastrin secretion than the chopped test meal.

  • The importance of an inter-compartmental delay in a model for human gastric acid secretion Marino, Simeone; Ganguli, Suman; Joseph, Ian M.P.; Kirschner, Denise E. // Bulletin of Mathematical Biology;Nov2003, Vol. 65 Issue 6, p963 

    In this work we re-examine an existing model of gastric acid secretion. The model is a 2-compartment model of the human stomach accounting for regions where relevant cells (D, G, ECL and parietal cells) and proteins and acid they secrete (somatostatin, gastrin, histamine, and gastric acid,...

  • Chronic Alcoholism and Endogenous Gastrin. Treffot, M. J.; Tiscornia, Oswaldo M.; Palasciano, G.; Hage, G.; Sarles, Henri // American Journal of Gastroenterology;Jan1975, Vol. 63 Issue 1, p29 

    Presents a comparative analysis of modifications in gastrin blood levels carried out in control and in dogs chronically treated with ethanol, after the infusion of hormone-releasing agents from the antrum. Results of the series of experiments; Effects of chronic ethanol treatment on...

  • Pentagastrin-stimulated Gastric Acid Secretion in Acute and Chronic Gastritis. Wye-Poh Fung; Swee-Kok Lee; Cho-Yook Tye // American Journal of Gastroenterology;Oct1975, Vol. 64 Issue 4, p301 

    Presents a study which determined basal and pentagastrin-stimulated gastric acid secretion in patients with various types of gastritis and in control subjects. Basis of the histological diagnosis of gastritis; Materials and method used in the study; Mean basal and peak acid outputs in control...

  • The effect of growth hormone releasing peptide-2 on upper gastrointestinal contractile activity and food intake in conscious dogs. Kudoh, Katsuyoshi; Shibata, Chikashi; Funayama, Yuji; Fukushima, Kouhei; Ueno, Tatsuya; Hayashi, Keiichi; Inui, Akio; Bowers, Cyril; Sasaki, Iwao // Journal of Gastroenterology;2009, Vol. 44 Issue 4, p297 

    The aim of this study was to evaluate the effect of growth hormone releasing peptide (GHRP)-2, a synthetic ligand for the growth hormone secretagogue receptor, on upper gastrointestinal motility and food intake. Five neurally intact dogs and five dogs with vagotomy and pyloroplasty were equipped...

  • gastrin. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p331 

    An encyclopedia entry for "gastrin" is presented. It refers to a hormone produced by cells in the stomach lining. The hormone causes the stomach to produce more acid and helps to propel food through the digestive tract.

  • The Effect of Fasting on 24-Hour Intragastric Acidity and Plasma Gastrin Concentration. Lanzon-Milier, S.; Pounder, R. E. // American Journal of Gastroenterology;Feb1991, Vol. 86 Issue 2, p165 

    Nine healthy subjects underwent two 24-h studies, either when fed six standard meals by mouth or when fasting. There was no significant difference in the median integrated 24-h intragastric acidity when fed or when fasting, 805 or 801 mmol â‹… h/L, respectively. However, the median...

  • RELEASE OF GASTRIN RY VAGAL STIMULATION IN THE ACID SECRETORY RESPONSE TO FOOD. Hunt, D. R.; Forrest, A. P. M. // Australian Journal of Experimental Biology & Medical Science;Apr1976, Vol. 54 Issue 2, p181 

    Gastric pouches were constructed in 8 dogs; in 4 they were of denervated type and in 4 the innervation was intact. An oesophageal fistula was then prepared in each dog. The acid secretory response to oral, tube and sham feeding was determined before and after denervation of the pyloric antrum....

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics