TITLE

Absorption of Orally Administered Digoxin After Massive Resection of the Small Bowel

AUTHOR(S)
Krausz, Michael M.; Berry, Elliot; Freund, Uri; Levy, Micha
PUB. DATE
February 1979
SOURCE
American Journal of Gastroenterology;Feb1979, Vol. 71 Issue 2, p220
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Digoxin absorption was studied in a patient after massive small bowel resection (with only 15 cm. of jejunum left) after mesenteric thrombosis. Oral administration of 0.25 mg. digoxin tablets resulted in therapeutic blood levels between 0.7 and 2.2 ng./ml. Measurement of the urinary excretion of the drug in steady state revealed more than 80% of the maintenance dose. Renal digoxin clearance was 125 ml./min. This resulted in slowing of the heart rate from 120 to 80/min. with no side-effects. It is thus concluded that total absorption of digoxin might be normal in a patient with only 15 cm. of jejunum and that usual dogs of digoxin were sufficient for a therapeutic effect and "therapeutic" blood levels.
ACCESSION #
16133801

 

Related Articles

  • Increased absorption of digoxin from the human jejunum due to inhibition of intestinal transporter-mediated efflux. Igel, Svitlana; Drescher, Siegfried; Mürdter, Thomas; Hofmann, Ute; Heinkele, Georg; Tegude, Heike; Glaeser, Hartmut; Brenner, Stefanie S.; Somogyi, Andrew A.; Omari, Taher; Schäfer, Christian; Eichelbaum, Michel; Fromm, Martin F.; Mürdter, Thomas; Schäfer, Christian // Clinical Pharmacokinetics;2007, Vol. 46 Issue 9, p777 

    Background and Objectives: The contribution of transport in the small intestine by the apically located efflux pump P-glycoprotein to variable drug absorption in humans is still poorly understood. We therefore investigated whether inhibition of intestinal P-glycoprotein-mediated...

  • Influence of Digoxin Immune Fab Therapy and Renal Dysfunction on the Disposition of Total and Free Digoxin. Ujbelyi, Michael R.; Robert, Sylvie; Cummings, Doyle M.; Colucci, Robert D.; Green, Paul J.; Sailstad, Jeffrey; Vlasses, Peter H.; Zarowitz, Barbara J. // Annals of Internal Medicine;8/15/93, Vol. 119 Issue 4, p273 

    Features a study that characterized the disposition of total and free serum digoxin following the administration of digoxin Fab antibody in patients with varying degrees of renal function. Patient characteristics and laboratory values at admission; Pharmacokinetic parameters of free digoxin;...

  • Digitalis Serum Levels: Clinical Use. Doherty, James E. // Annals of Internal Medicine;May71, Vol. 74 Issue 5, p787 

    Editorial. Emphasizes the clinical significance of the drug digitalis serum. Physiological implications of digitalis serum levels; Technique in measuring digitalis serum levels; Relationship between digoxin serum concentration and myocardial concentration of the drug.

  • Desirudin: A Review of its Use in the Management of Thrombotic Disorders. Matheson, A.J.; Goa, K.L. // Drugs;Sep2000, Vol. 60 Issue 3, p679 

    Desirudin, a recombinant hirudin used in the prevention and management of thromboembolic disease, is a thrombin inhibitor which binds directly and with high affinity to clot-bound and fluid phase thrombin. As a prophylaxis in patients undergoing hip replacement surgery, desirudin was...

  • Lenalidomide.  // Reactions Weekly;5/10/2008, Issue 1201, p20 

    The article describes the case of a man who developed episodes of venous thrombosis while being administered lenalidomide for myelofibrosis. Heparin was used to treat the man's thromboembolism. Warfarin was given as an anticoagulant and lenalidomide was reinitiated. When warfarin was stopped he...

  • Clinical Pharmacokinetics and Pharmacodynamics of Linagliptin. Graefe-Mody, Ulrike; Retlich, Silke; Friedrich, Christian // Clinical Pharmacokinetics;2012, Vol. 51 Issue 7, p411 

    Linagliptin is an orally active small-molecule inhibitor of dipeptidyl peptidase (DPP)-4, which was first licensed in the US, Europe, Japan and other territories in 2011 to improve glycaemic control in adults with type 2 diabetes mellitus. Linagliptin is the first and thus far the only DPP-4...

  • Digoxin.  // Reactions Weekly;8/10/2013, Issue 1465, p16 

    An abstract of the article "Fetal supraventricular tachycardia, treating the baby by targeting the mother," by A. Husain and colleagues is presented.

  • No Interaction between Hawthorn and Digoxin Suggested in Human Study. Brown, Donald J. // HerbalGram;Winter2004, Issue 61, p30 

    Studies the potential interactions and effects of hawthorn on the conventional cardiotonic drug digoxin's pharmacokinetic parameters. Blood collection for determination of digoxin renal clearance; Pharmacodynamic measurements.

  • Digoxin interaction.  // Reactions Weekly;3/12/2005, Issue 1042, p10 

    Discusses research being done on the interaction between clarithromycin and digoxin in patients with end-stage renal disease. Reference to a study by S. Hirata, S. Izumi, T. Furukubo published in the January 2005 issue of the "International Journal of Clinical Pharmacology and Therapeutics";...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics