TITLE

BCG Treatment of Crohn's Disease

AUTHOR(S)
Rahban, Said; Sherman, James H.; Opelz, Gerhard; Conley, Dean R.; Panish, Joel F.; Marks, Jay W.; Terasaki, Paul I.; Schoenfield, Leslie J.
PUB. DATE
February 1979
SOURCE
American Journal of Gastroenterology;Feb1979, Vol. 71 Issue 2, p196
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Among 53 patients with documented Crohn's disease, 30% manifested a defect in delayed hypersensitivity demonstrated by negative DNCB skin tests and significant (p < 0.01) T-Iympliocyte hyporeactivity. A double-blind controlled trial was conducted to evaluate oral Bacillus Calmette-Guerin (BCG) therapy in nine of these patients with Crohn's disease and deficient cellular immunity. All patients had a Crohn's Disease Activity Index (CDAl) greater than 150 (at least moderate activity) upon randomizaion to BCG (five patients) or placebo (four patients) treatment for six to 12 months. No significant differences between BCG and placebo treatment were found in the CDAI, laboratory tests and gastrointestinal roentgenograms. We conclude that the disturbance in cell-mediated immunity in patients with Crohn's disease probably is a manifestation of the disease rather than an etiological factor and that immunostimulation with oral BCG is not effective therapy.
ACCESSION #
16133791

 

Related Articles

  • Post-BCG skin testing. M.O.R. // Cortlandt Forum;09/25/97, Vol. 10 Issue 9, p157 

    Explains why a skin test may be positive many years after a child has received Calmette-Guerin vaccine. Age at which the vaccination is given; Importance of elapsed time since vaccination.

  • Mesalamine for Crohn's disease improves quality of life.  // Modern Medicine;Oct95, Vol. 63 Issue 10, p50 

    Presents an abstract of the article `Quality-of-Life Results of Double-Blind, Placebo-Controlled Trial of Mesalamine in Patients With Crohn's Disease,' by J.W. Singleton, S. Hanauer and M. Robinson which was featured in a science journal dated May 1995.

  • Maintenance infliximab infusions forever? Lee, Scott D.; Surawicz, Christina M. // American Journal of Gastroenterology;Nov2002, Vol. 97 Issue 11, p2917 

    The authors undertook a randomized controlled trial to assess the benefit of maintenance infliximab therapy in patients with active Crohn’s disease defined as having a Crohn’s Disease Activity Index ≥220. Initially, 573 patients were given a single dose of infliximab. The 335...

  • Budesonide CIR capsules (once or twice daily divided-dose) in active Crohn’s disease: a randomized placebo-controlled study in the United States. Tremaine, William J.; Hanauer, Stephen B.; Katz, Seymour; Winston, Barry D.; Levine, Jeffrey G.; Persson, Tore; Persson, Anders // American Journal of Gastroenterology;Jul2002, Vol. 97 Issue 7, p1748 

    OBJECTIVES:Budesonide controlled ileal release (CIR) capsules deliver budesonide, a glucocorticosteroid with high topical and low systemic activity, to the distal ileum and the proximal colon. In four previous controlled trials in Crohn’s disease, remission rates ranged from 51% to 69%....

  • Natalizumab for active Crohn's disease. Ghosh, S. // Gut;Jul2003, Vol. 52 Issue 7, p1068 

    Discusses the article 'Natalizumab for Active Crohn's Disease,' by S. Ghosh, E. Goldin, F.H. Gordon et al, published in a 2003 issue of 'New England Journal of Medicine.'

  • Modulation of humoral immune response to oral BCG vaccination by Mycobacterium bovis BCG Moreau Rio de Janeiro (RDJ) in healthy adults. Monteiro-Maia, Renata; Ortigão-de-Sampaio, Maria B.; Pinho, Rosa T.; Castello-Branco, Luiz R. R. // Journal of Immune Based Therapies & Vaccines;2006, Vol. 4, p1 

    Background: Oral administration of BCG was the route initially used by Calmette and Guérin, but was replaced by intradermal administration in virtually all countries after the Lubeck accident. However, Brazil continued to administer oral BCG Moreau RDJ, which was maintained until the...

  • Monocyte response receptors in BCG driven delayed type hypersensitivity to tuberculin. Strapagiel, Dominik; Kasztalska, Karolina; Druszczyńska, Magdalena; Kowalewicz-Kulbat, Magdalena; Vrba, Adriana; Matusiak, Agnieszka; Chmiela, Magdalena; Rudnicka, Wiesława // Folia Histochemica et Cytobiologica;2008, Vol. 46 Issue 3, p353 

    Tuberculosis (TB) still remains the leading cause of mortality due to bacterial pathogen. The only currently available vaccine against TB, Bacille Calmette-Guérin (BCG) is at best credited with a 50% overall protective efficacy. Skin testing with purified protein derivative (PPD) from...

  • Mycobacterium tuberculosis PPD-induced immune biomarkers measurable in vitro following BCG vaccination of UK adolescents by multiplex bead array and intracellular cytokine staining. Smith, Steven G.; Lalor, Maeve K.; Gorak-Stolinska, Patricia; Blitz, Rose; Beveridge, Natalie E. R.; Worth, Andrew; McShane, Helen; Dockrell, Hazel M. // BMC Immunology;2010, Vol. 11, p35 

    Background: The vaccine efficacy reported following Mycobacterium bovis Bacillus Calmette Guerin (BCG) administration to UK adolescents is 77% and defining the cellular immune response in this group can inform us as to the nature of effective immunity against tuberculosis. The aim of this study...

  • Effect of revaccination with BCG in early childhood on mortality: randomised trial in Guinea-Bissau. Roth, Adam Edvin; Benn, Christine Stabell; Ravn, Henrik; Rodrigues, Amabelia; Lisse, Ida Maria; Yazdanbakhsh, Maria; Whittle, Hilton; Aaby, Peter // BMJ: British Medical Journal (Overseas & Retired Doctors Edition;4/3/2010, Vol. 340 Issue 7749, p749 

    The article discusses a study which investigated the effect of revaccination with BCG in early childhood on mortality. The randomised trial conducted in Guinea-Bissau involved 2,871 children aged 19 months to 5 years registered in the study area of Bandim Health Project. The researchers observed...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics