Intractable Cough and Abnormal Pulmonary Function in Benign Recurrent Intrahepatic Cholestasis

Chatila, Rajaa; Bergasa, Nora V.; Lagarde, Suzanne; West, A. Brian
October 1996
American Journal of Gastroenterology;Oct1996, Vol. 91 Issue 10, p2215
Academic Journal
Benign recurrent intrahepatic cholestasis (BRIC) is a syndrome characterized by recurrent episodes of cholestasis with associated pruritus. The intensity and duration of cholestatic episodes, and the length of the intervening periods, vary. unpredictably. We report the case of a patient with BRIC who was incapacitated by a severe intractable cough that accompanied marked pruritus during her second cholestatic episode. No cause for the cough was found, and it resolved spontaneously with amelioration of mild restrictive abnormalities of pulmonary function as the cholestasis subsided. Although cough has not been recognized as a complication of cholestasis, we postulate that it may occur either (i) as a result of direct stimulation of sensory nerves by circulating humoral substances related to the cholestasis that act either peripherally in the airways or centrally, or (ii) through stimulation of the vagus nerve in the liver, leading to cough that is mediated either centrally or by reflex.


Related Articles

  • Propofol and Cholestatic Pruritus. Borgeat, Alain; Wilder-Smith, Oliver; Mentha, Gilles; Huber, Olivier // American Journal of Gastroenterology;May1992, Vol. 87 Issue 5, p672 

    Hepatic cholestatis is frequently associated with pruritus. This pruritus is often intractable and resistant to conventional treatment. We treated three patients with intractable cholestatic pruritus with subhypnotic doses of propofol, a new intravenous anesthetic induction agent. All patients...

  • Endoscopic Retrograde Cholangiopancreatography Study in Alagille's Syndrome: First Report. Morelli, A.; Pelli, M. A.; Vedovelli, A.; Narducci, F.; Solinas, A.; De Benedictis, F. M. // American Journal of Gastroenterology;Apr1983, Vol. 78 Issue 4, p241 

    Endoscopic retrograde cholangiopancreatography revealed the association between intra- and extra-hepatic biliary tree bypoplasia in an 8-year-old boy affected by Alagille's syndrome. The patient, in whom chronic cholestasis bad been present from birth, presented characteristic facies, retarded...

  • cholestasia.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p439 

    An encyclopedia entry for "cholestasia" is presented.

  • cholestasis.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p439 

    A definition of the term "cholestasis" which refers to the arrest of the flow of bile is presented.

  • Management of the Pruritus of Cholestasis: Potential Role of Opiate Antagonists. Bergasa, Nora V.; Jones, E. Anthony // American Journal of Gastroenterology;Oct1991, Vol. 86 Issue 10, p1404 

    Examines the potential role of opiate antagonists in the management of the pruritus of cholestasis. Information on pruritus in patients with cholestatic liver diseases; List of conventional and resourceful treatments; Assessment of pruritus in cholestatic patients.

  • Hepatic damage in biliary-obstructed rats is ameliorated by leflunomide treatment. Karaman, Abdurrahman; Iraz, Mustafa; Kirimlioglu, Hale; Karadag, Nese; Tas, Erkan; Fadillioglu, Ersin // Pediatric Surgery International;Sep2006, Vol. 22 Issue 9, p701 

    Cholestasis, or impaired bile flow, occurs in a wide variety of liver diseases and causes hepatic damage by retention and accumulation of toxic hydrophobic bile salts inducing persistent inflammation and oxidative stress. In the present research, we studied the effect of leflunomide, a novel...

  • Prevalence of Intrahepatic Cholestasis of Pregnancy in Chile. Reyes, Humberto; Gonzalez, Manuel C.; Ribalta, Jose; Aburto, Hector; Matus, Claudio; Schramm, German; Katz, Ricardo; Medina, Ernesto // Annals of Internal Medicine;Apr78, Vol. 88 Issue 4, p487 

    Provides information on a study that investigated the prevalence of intrahepatic cholestasis of pregnancy immediately postpartum in women from three distant cities in Chile differing in climate and food. Methodology of the study; Results and discussion on the study.

  • Pruritus in pregnancy. Orr, Barbara; Usatine, Richard P. // Journal of Family Practice;Nov2007, Vol. 56 Issue 11, p913 

    The article presents a clinical case involving a 32-year-old pregnant mother who had excoriations all over her body but no blistering. Clinical examination shows that she had intrahepatic cholestasis of pregnancy (ICP), a disorder caused by maternal intrahepatic bile secretory dysfunction. Also...

  • Questions in Gastroenterology. Hazzi, Charles G. // American Journal of Gastroenterology;Oct1981, Vol. 76 Issue 4, p388 

    Presents a series of questions about topics related to gastroenterology, including hyperplastic gastropathy, pruritus of cholestasis, and postvagotomy dysphagia.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics