Esophageal Epithelial Defenses Against Acid Injury

Orlando, Roy c.
August 1994
American Journal of Gastroenterology;Aug1994 Supplement, Vol. 89 Issue 8, pS48
Academic Journal
Discusses esophageal epithelial defenses against acid injury. Reason only a minority of those at risk of gastroesophageal relux ever develop recurrent symptoms or signs of esophageal damage; Discussion on the ability of the apical cell membrane of esophageal epithelial cells to resist acid penetration; Postepithelial factors that provide protection against acid injury to the tissue;


Related Articles

  • The Genesis of Barrett Esophagus. Riddell, Robert H. // Archives of Pathology & Laboratory Medicine;Feb2005, Vol. 129 Issue 2, p164 

    Has a histologic transition from gastroesophageal reflux disease-damaged epithelium to columnar metaplasia ever been seen in humans? The answer to this question seems to be that it has but that we either do not readily recognize it or it is not readily recognizable with regular light microscopy....

  • Association between gastroesophageal flap valve, reflux esophagitis, Barrett's epithelium, and atrophic gastritis assessed by endoscopy in Japanese patients. Fujiwara, Yasuhiro; Higuchi, Kazuhide; Shiba, Masatsugu; Watanabe, Toshio; Tominaga, Kazunari; Oshitani, Nobuhide; Matsumoto, Takayuki; Arakawa, Tetsuo // Journal of Gastroenterology;2003, Vol. 38 Issue 6, p533 

    Background. Endoscopic grading of the gastroesophageal flap valve (GEFV) is a useful predictor of gastroesophageal reflux status; abnormal GEFV was associated with reflux esophagitis. Atrophic gastritis is often found in Japanese patients and is inversely related to reflux esophagitis. The aim...

  • Symptoms, acid exposure and motility in patients with Barrett's esophagus. Brandt, Michael G.; Darling, Gail E.; Miller, Linda // Canadian Journal of Surgery;Feb2004, Vol. 47 Issue 1, p47 

    Introduction: Barrett's esophagus, a syndrome in which the squamous mucosa that normally lines the distal esophagus is replaced with columnar epithelium, is found in a small percentage of patients presenting with gastroesophageal reflux disease (GERD). The columnar epithelium may be...

  • Towards the molecular characterization of disease: comparison of molecular and histological analysis of esophageal epithelia. Vallböhmer, Daniel; Marjoram, Paul; Kuramochi, Hidekazu; Shimizu, Daisuke; Hsuan Jung; DeMeester, Steve R.; Oh, Daniel; Chandrasoma, Parakrama T.; Danenberg, Kathleen D.; DeMeester, Tom R.; Danenberg, Peter V.; Peters, Jeffrey H.; Vallböhmer, Daniel; Jung, Hsuan // Journal of Gastrointestinal Surgery;Sep2007, Vol. 11 Issue 9, p1095 

    Reliable quantification of gene expression offers the possibility of more accurate and prognostically relevant characterization of tissues than potentially subjective interpretations of histopathologists. We measured the expression of 18 selected genes and compared them to histological features...

  • gastroesophageal reflux disease.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p932 

    An encyclopedia entry for "gastroesophageal reflux disease," which refers to a condition wherein the acid from the stomach flows back into the esophagus, causing damage to the esophageal lining, is presented.

  • Latest thinking in Barrett's esophagus: Heading off esophageal cancer. Spechler, Stuart Jon; Russell, Julia // Patient Care;Sep2005, Vol. 39 Issue 9, p46 

    Provides information on Barrett's esophagus, which is usually identified during endoscopic evaluation of patients with chronic symptoms of gastroesophageal reflux disease. Diagnosis of Barett's esophagus; Types of columnar epithelium which have been described in mucosa with the gross appearance...

  • Relevance of volume and proximal extent of reflux in gastrooesophageal reflux disease. Sifrim, D. // Gut;Feb2005, Vol. 54 Issue 2, p175 

    In patients with gastro-oesophageal reflux disease (GORD), oesophageal and extraoesophageal symptoms are traditionally attributed to increased contact time beiween the mucosa and refluxates. However, the volume of reflux may be important by increasing the total amount of highly concentrated...

  • The Relationship between Gastroesophageal Reflux Disease and Its Complications with Barrett's Esophagus. Eisen, G. M.; Sandler, R. S.; Murray, S.; Gottfried, M. // American Journal of Gastroenterology;Jan1997, Vol. 92 Issue 1, p27 

    Background: Barrett's esophagus is a condition in which the stratified squamous epithelium of the esophagus is replaced by a columnar epithelium with malignant potential. Chronic gastroesophageal reflux disease (GERD) is accepted as the primary risk factor for the development of Barrett's...

  • Specialized Columnar Epithelium of the Esophagogastric Junction: Prevalence and Associations. Voutilainen, Markku; Färkkilä, Martti; Juhola, Matti; Nuorva, Kyösti; Mauranen, Kari; Mäntynen, Timo; Kunnamo, Ilkka; Mecklin, Jukka-Pekka; Sipponen, Pentti // American Journal of Gastroenterology;Apr1999, Vol. 94 Issue 4, p913 

    OBJECTIVES: In Barrett's esophagus (BE) normal squamous esophageal epithelium is replaced by specialized columnar epithelium (SCE). BE is related to astroesophageal reflux disease (GERD) and is a risk factor for esophageal adenocarcinoma. SCE is detected also at normal-appearing esophagogastric...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics