Acute Cholestatic Hepatitis Associated With Pravastatin

Hartleb, Marek; Rymarczyk, Grzegorz; Januszewski, Krzysztof
May 1999
American Journal of Gastroenterology;May1999, Vol. 94 Issue 5, p1388
Academic Journal
A 57-yr-old man presented with clinical and laboratory signs of acute cholestatic hepatitis. Symptoms had appeared 7 wk after he was started on pravastatin 20 mg/day for hypercholesterolemia. A full evaluation including ultrasound, computed tomography, endoscopic cholangiography, and liver biopsy confirmed the diagnosis of intrahepatic nonobstructive jaundice. The liver function abnormalities normalized 7 wk after cessation of therapy. Pravastatin should be considered as a potential cause of cholestatic hepatitis with favorable clinical outcome after drug withdrawal.


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