TITLE

Treatment of Gastric MALT Lymphoma by Helicobacter pylori Eradication: A Study Controlled by Endoscopic Ultrasonography

AUTHOR(S)
Nobre-Leitão, C.; Lage, P.; Cabeçadas, J.; Chaves, P.; Alberto-Santos, A.; Correia, J.; Soares, J.; Costa-Mira, F.; Cravo, M.
PUB. DATE
May 1998
SOURCE
American Journal of Gastroenterology;May1998, Vol. 93 Issue 5, p732
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: Previous studies have demonstrated a link between Helicobacter pylori infection and low grade B-cell gastric MALT lymphoma. The aim of this study was to evaluate the effect of Helicobacter pylori eradication in 17 patients with low grade B-cell gastric MALT lymphoma stage EI. Methods: For disease staging EUS and CT scan were systematically performed. Eight patients were excluded from the present series because stage EII disease was diagnosed. To demonstrate B-cell monoclonality, immunohistochemistry and polymerase chain reaction were used. H. pylori eradication was performed with triple therapy. Results: H. pylori was eradicated in all patients after first (n = 15) or second line (n = 2) treatment. Histologic regression of lymphoma was observed in all patients after a median period of 2 mo. Disappearance of monoclonality according to polymerase chain reaction took significantly longer (7 mo). At the end of the study, four of 16 patients still exhibited persistent monoclonal bands. Relapse of lympboma occurred in two patients associated with H. pylori reinfection/recrudescence. Conclusion: Eradication of H. pylori seems to be an effective therapy in patients with stage EI gastric MALT lymphoma, although long-term results are still uncertain. Endoscopic ultrasonography is useful for a more accurate staging of the disease. The clinical significance of detecting monocionallty by polymerase chain reaction remains to be determined.
ACCESSION #
16070889

 

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