A Double-Blind Multicenter Comparison of Domperidone and Metoclopramide in the Treatment of Diabetic Patients With Symptoms of Gastroparesis

Patterson, David; Abell, Thomas; Rothstein, Robin; Koch, Kenneth; Barnett, Jeffrey
May 1999
American Journal of Gastroenterology;May1999, Vol. 94 Issue 5, p1230
Academic Journal
OBJECTIVE: A double-blind, multicenter, randomized trial was conducted to compare the side effects and efficacy of domperidone and metoclopramide in symptomatic diabetic gastroparesis. METHODS: Ninety-three insulin-dependent diabetes patients with a ≥ 3-month history of gastroparesis symptoms were recruited: 48 received domperidone 2 x 10-mg tablets 4 times daily, and 45 received metoclopramide 1 x 10-mg tablet + 1 placebo tablet 4 times daily. Nausea, vomiting, bloating/distension, and early satiety were evaluated for severity after 2 and 4 wk. Adverse central nervous system (CNS) effects of somnolence, akathisia, asthenia, anxiety, depression, and reduced mental acuity were elicited and graded for severity at 2 and 4 wk. RESULTS: Domperidone and metoclopramide were equally effective in alleviating symptoms of diabetic gastroparesis. Elicited adverse CNS effects were more severe and more common with metoclopramide. Somnolence was acknowledged by 49% of patients (mean severity score, 1.03) after 4 wk of metoclopramide compared with 29% of patients (mean severity score, 0.49) after 4 wk of domperidone (incidence, p = 0.02: severity: p = 0.03). A reduction in mental acuity was acknowledged by 33% of patients (mean severity score, 0.62) after 4 wk of metoclopramide, compared with 20% of patients (mean severity score, 0.27) after 4 wk of domperidone (incidence, p = 0.04; severity, p = 0.04). Akathisia, asthenia, anxiety, and depression were also acknowledged less often, and at a lower severity, after 4 wk of domperidone, although these differences were not statistically significant. CONCLUSIONS: Domperidone and metoclopramide effectively reduce the symptoms of diabetic gastroparesis: CNS side effects are more pronounced with metoclopramide.


Related Articles

  • Terlipressin.  // Reactions Weekly;9/12/2009, Issue 1269, p33 

    The article describes the case of a 45-year-old patient who developed diabetic muscle infarction during treatment with terlipressin for gastrointestinal bleeding. The patient experienced increasing pain in his right posterior thighs. A tender swollen mass over his right posterior thigh was noted...

  • READERS SOUND OFF.  // Diabetes Health;Jun/Jul2008, Vol. 17 Issue 3, p16 

    The article presents the views of several readers on the effectiveness of the drug Byetta in managing diabetes. A reader says the drug is good for most diabetics, but not for those who have intestinal problems. One reader cites several benefits associated with Byetta which include decreased...

  • Pooled Analysis of 7 Randomized, Controlled Trials of Pregabalin as Treatment of Painful Diabetic Peripheral Neuropathy (DPN): Efficacy, Safety, Tolerability. Freeman, R.; Rosenstock, J.; Emir, B.; Durso-Decruz, E. // Diabetes;Jun2007 Supplement 1, Vol. 56, pA577 

    To more fully describe pregabalin as treatment of painful DPN across its effective dosing range (150-600 mg/d, BID or TID), we pooled data from 7 randomized controlled trials of 5-13 weeks' duration. 1510 patients comprised the pooled ITT population: 557 received placebo (PBO), and 953 received...

  • Diuretic therapy for older patients with type II diabetes. Huffman, Grace Brooke // American Family Physician;6/1/1997, Vol. 55 Issue 8, p2797 

    Presents a summary of the article `Effect of Diuretic-based Antihypertensive Treatment on Cardiovascular Disease Risk in Older Diabetic Patients with Isolated Systolic Hypertension,' by J.D. Curb, et al from the `Journal of American Medical Association' dated 1996. Effects of diuretics in...

  • Ranirestat for the Management of Diabetic Sensorimotor Polyneuropathy. Bril, Vera; Hirose, Toshiyuki; Tomioka, Sasagu; Buchanan, Robert // Diabetes Care;Jul2009, Vol. 32 Issue 7, p1256 

    OBJECTIVE -- Aldose reductase inhibitors (ARIs) are potential disease modifiers for diabetes complications. We aimed to determine whether ranirestat, an ARI, could slow or reverse the course of diabetic sensorimotor polyneuropathy (DSP). RESEARCH DESIGN AND METHODS-- A total of 549 patients with...

  • domperidone. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p242 

    An encyclopedia entry for "domperidone," is presented. It is an antiemetic drug that is used to relieve nausea and vomiting, associated with gastrointestinal disorders or during radiotherapy. According to this entry, adverse effects of domperidone include breast enlargement and secretion of milk...

  • Oral adverse effects of gastrointestinal drugs and considerations for dental management in patients with gastrointestinal disorders. Karthik, Ramya; Karthik, K. S.; David, Chaya; Ameerunnisa; Keerthi, G. // Journal of Pharmacy & Bioallied Sciences;Aug2012 Supplement, pS239 

    Gastrointestinal disease is associated with alterations in the mouth or influence the course of the dental diseases, and the dental health care workers are expected to recognize, diagnose, and treat oral conditions associated with gastrointestinal diseases and also provide safe and appropriate...

  • Lithium-induced nephrogenic diabetes insipidus in older people. Mukhopadhyay, Diptarup; Gokulkrishnan, Lingesan; Mohanaruban, Kanthaya // Age & Ageing;Jul2001, Vol. 30 Issue 4 

    Presents a case of lithium-induced nephrogenic diabetes insipidus in older people. Exhibition of partial nephrogenic diabetes insipidus following a water-deprivation test; Correlation between impaired urinary concentrating ability and duration of lithium therapy; Effect of reducing lithium...

  • Alpha-lipoic Acid.  // Alternative Medicine Review;Sep2006, Vol. 11 Issue 3, p232 

    The article provides information on alpha-lipoic acid (ALA). It is an antioxidant which appears to be readily absorbed from an oral dose and converts easily to its reduced form in many tissues of the body. Mechanisms that may account for its benefit in preventing diabetic complications include...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics