Elevated Interleukin-6 and &gamma:-Globulin during Interferon Therapy of Hepatitis B

Itoh, Yoshito; Okanoue, Takeshi; Enjyo, Fumio; Morimoto, Michio; Takeuchi, Takayuki; Kagawa, Keizo; Kashima, Kei
October 1992
American Journal of Gastroenterology;Oct1992, Vol. 87 Issue 10, p1485
Academic Journal
A 49-yr-old man with chronic hepatitis B manifested hypergammaglobulinemia, lymphadenopathy, and a high serum interleukin-6 level following treatment with recombinant human α-interferon. One month later, when the patient was treated with natural β-interferon, serum levels of interleukin-6 and γ-globulin increased again. The serum γ-globulin decreased to the pretreatment level after discontinuation of interferon therapy. The serum alanine aminotransferase level remained normal for 6 months. In this case, hypergammaglobulinemia and lymphadenopathy, as well as the elevated serum interleukin-6 level, were considered to be signs of highly enhanced humoral immunity related to α- and β-interferon therapy.


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