TITLE

Elevated Interleukin-6 and &gamma:-Globulin during Interferon Therapy of Hepatitis B

AUTHOR(S)
Itoh, Yoshito; Okanoue, Takeshi; Enjyo, Fumio; Morimoto, Michio; Takeuchi, Takayuki; Kagawa, Keizo; Kashima, Kei
PUB. DATE
October 1992
SOURCE
American Journal of Gastroenterology;Oct1992, Vol. 87 Issue 10, p1485
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A 49-yr-old man with chronic hepatitis B manifested hypergammaglobulinemia, lymphadenopathy, and a high serum interleukin-6 level following treatment with recombinant human α-interferon. One month later, when the patient was treated with natural β-interferon, serum levels of interleukin-6 and γ-globulin increased again. The serum γ-globulin decreased to the pretreatment level after discontinuation of interferon therapy. The serum alanine aminotransferase level remained normal for 6 months. In this case, hypergammaglobulinemia and lymphadenopathy, as well as the elevated serum interleukin-6 level, were considered to be signs of highly enhanced humoral immunity related to α- and β-interferon therapy.
ACCESSION #
16070264

 

Related Articles

  • IL28B polymorphism predictive of surface antigen serodearance in chronic HBV patients.  // Infectious Disease News;Apr2013, Vol. 26 Issue 4, p30 

    The article discusses a study which found that interleukin 28B polymorphism is a reliable predictor of the outcome of interferon-based therapy for chronic hepatitis B.

  • Liver disease is a worldwide threat.  // USA Today Magazine;Feb95, Vol. 123 Issue 2597, p5 

    Reports on hepatitis B as the ninth leading cause of death in the world. Risk factors for hepatitis B; Interferon as an effective treatment for about 40% of hepatitis B patients; Side effects.

  • HBV replication is significantly reduced by IL-6. Tzer-Min Kuo; Cheng-po Hu; Ya-Ling Chen; Ming-Hsiang Hong; King-Song Jeng; Liang, Chun-Chin T.; Mong-Liang Chen; Chungming Chang // Journal of Biomedical Science;2009, Vol. 16, p1 

    Interleukin-6 (IL-6) is a pleiotropic cytokine with pivotal functions in the regulation of the biological responses of several target cells including hepatocytes. The level of serum IL-6 has been reported to be elevated in patients with chronic hepatitis B, cirrhosis and hepatocellular carcinoma...

  • Detecting Minimal Hepatic Encephalopathy in an Endemic Country for Hepatitis B: The Role of Psychometrics and Serum IL-6. Tsai, Chia-Fen; Chu, Chi-Jen; Huang, Yi-Hsiang; Wang, Yen-Po; Liu, Pei-Yi; Lin, Han-Chieh; Lee, Fa-Yauh; Lu, Ching-Liang // PLoS ONE;Jun2015, Vol. 10 Issue 6, p1 

    Background & Aims: It remains unknown what the prevalence of minimal hepatic encephalopathy is in Taiwan, a highly endemic country for chronic viral hepatitis infection. It is also unclear whether abnormal serum cytokine levels can be indicative of the presence of minimal hepatic...

  • Systemic juvenile idiopathic arthritis mimics multicentric Castleman’s disease. Osone, Shinya; Morimoto, Akira; Tsutsui, Junna; Kano, Gen; Todo, Shinjiro; Sugimoto, Tohru // Clinical Rheumatology;Dec2003, Vol. 22 Issue 6, p484 

    An 11-year-old girl presented with fever and a large cervical lymphadenopathy. Indicators of inflammation were remarkable: she had extremely high levels of serum interleukin-6 (IL-6) (398 pg/ml) in addition to hypergammaglobulinemia and hypoalbuminemia. Computed tomography (CT) revealed swollen...

  • HBV: Alpha interferon works, but you might want to hold off using it.  // Modern Medicine;Mar94, Vol. 62 Issue 3, p62 

    Presents an abstract of the article entitled `Effect of Alpha-Interferon Treatment in Patients with Hepatitis B e Antigen-Positive Chronic Hepatitis B: A Meta-Analysis,' by D.K.H. Wong, A.M. Cheung, et al, published in the August 15, 1993 issue of the `Annals of Internal Medicine.'

  • Cost-effectiveness of inteferon-alpha2b treatment for hepatitis B e antigen-positive chronic... Wong, John B.; Koff, Raymond S. // Annals of Internal Medicine;5/1/95, Vol. 122 Issue 9, p664 

    Evaluates the cost-effectiveness of interferon-alpha2B for the treatment of patients with chronic hepatitis B infection who are positive for hepatitis B e antigen (HBeAg). Meta-analysis of nine randomized controlled trials and cost-effectiveness analysis; Lifetime incidence of cirrhosis and...

  • Comparison of 12-Month Courses of Interferon-α -2b--Lamivudine Combination Therapy and Interferon-α -2b Monotherapy among Patients with Untreated Chronic Hepatitis B. Yalcin, Kendal; Degertekin, Halil; Yildiz, Fetin; Celik, Yusuf // Clinical Infectious Diseases;6/15/2003, Vol. 36 Issue 12, p1516 

    We compared the use of prolonged synchronous combination therapy with interferon (IFN)-α-2b and lami-vudine with the use of IFN-α-2b monotherapy in patients with untreated hepatitis B e antigen (HBeAg)-positive chronic hepatitis B virus (HBV) infection. Thirty-three patients received...

  • Alpha-IFN of Little Value in HBV-MPGN.  // Kidney;Jan/Feb98, Vol. 7 Issue 1, p39 

    Evaluates the therapeutic effect of alpha-interferon on hepatitis B-virus associated glomerulonephritis (HBV-GN). Ineffectiveness of alpha-interferon in the membranoproliferative glomerulonephritis type of HBV-GN.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics