Intestinal Herpes Simplex Infection Presenting with Intestinal Perforation

Wasselle, Joseph A.; Sedgwick, Jacqueline H.; Dawson, Peter J.; Fabri, Peter J.
October 1992
American Journal of Gastroenterology;Oct1992, Vol. 87 Issue 10, p1475
Academic Journal
A 77-yr-old man who had received systemic steroids for more than 6 yr presented with an acute abdomen. Laparotomy revealed an ulcerative jejunitis with purulent peritonitis. The patient underwent resection of involved bowel followed by a 10-day course of aciclovir, with excellent results. Pathologic examination showed a necrotizing enteritis with intranuclear inclusions typical of Herpesvirus that reacted immunocytochemically with antibodies to herpes simplex virus types I and II. A rising herpes simplex virus serum antibody titer confirmed the diagnosis. Intestinal herpes infection with perforation should be added to the list of complications from herpes simplex in the immunocompromised patient.


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