Ornithine Decarboxylase: An Unreliable Marker for the Identification of Population Groups at Risk for Colonic Neoplasia

Braverman, Dan Z.; Stankiewicz, Halina; Goldstein, Robert; Patz, Julian K.; Morali, Gilles A.; Jacobsohn, Warren Z.
June 1990
American Journal of Gastroenterology;Jun1990, Vol. 85 Issue 6, p723
Academic Journal
Ornithine decarboxylase (ODC) is the first and rate-limiting enzyme in the polyamine biosynthetic pathway. Polyamines have been studied as potential markers of neoplastic diseases, including colonic cancer. Previous studies have pointed out the possible value of this enzyme as a biochemical marker of colonic neoplasia, we studied 100 patients undergoing diagnostic total colonoscopy. There were 40 normal controls and 20 patients in each of the following groups: 1) family members of patients diagnosed as having colonic tumors, 2) patients with adenomas, and 3) patients with colonic adenocarcinoma. Six forceps biopsies were obtained from the normal-appearing sigmoid mucosa for the analysis of ODC. No difference was found among the four groups studied. We therefore conclude that ODC is unreliahle for clinical use as a biochemical marker for the identification of population groups at risk for colonic neoplasia.


Related Articles

  • Low-Dose Diflouromethylornithine and Polyamine Levels in Human Prostate Tissue. Messing, Edward M.; Love, Richard R. // JNCI: Journal of the National Cancer Institute;08/18/99, Vol. 91 Issue 16, p1416 

    Features a study on the effects of difluoromethylornithine on human peripheral zone prostatic ornithine decarboxylate activities and polyamine levels in patients undergoing open prostatic surgery. Measurement of testosterone, prostate-specific antigen, and prostatic acid phosphatase levels;...

  • Polyamine depletion induces G1 and S phase arrest in human retinoblastoma Y79 cells. Ueda, Akiko; Araie, Makoto; Kubota, Shunichiro // Cancer Cell International;2008, Vol. 8, Special section p1 

    Background: Polyamines and ornithine decarboxylase (ODC) are essential for cell proliferation. DL-α-difluoromethylornithine (DFMO), a synthetic inhibitor of ODC, induces G1 arrest through dephosphorylation of retinoblastoma protein (pRb). The effect of DFMO on cell growth of pRb deficient...

  • Ornithine Decarboxylase in Skin. Lesiewicz, Jeanne; Goldsmith, Lowell A. // Journal of Investigative Dermatology;Sep80, Vol. 75 Issue 3, p207 

    Ornithine decarboxylase (ODC) was discovered in animal tissues in 1968 [1,2] and interest in its activity and regulation has led to a rapidly and still expanding literature on the enzyme. Several comprehensive reviews have already appeared [3-6]. This article emphasizes our current knowledge of...

  • Cytostatic Properties of Some Angiotensin I Converting Enzyme Inhibitors and of Angiotensin II Type I Receptor Antagonists. A. Molteni; W.F. Ward; C.H. Ts'ao; J. Taylor; W. Small Jr.; L. Brizio-Molteni; P.A. Veno // Current Pharmaceutical Design;Apr2003, Vol. 9 Issue 9, p751 

    Angiotensin converting enzyme (ACE) inhibitors and angiotensin II (AII) type 1 receptor antagonists have strong cytostatic properties on in vitro cultures of many normal and neoplastic cells. They are effective, in particular, in reducing the growth of human lung fibroblasts, renal canine...

  • Glucocorticoids and Polyamine Inhibitors Synergize to Kill Human Leukemic CEM Cells. Miller, Aaron L.; Johnson, Betty H.; Medh, Rheem D.; Townsend, Courtney M.; Thompson, E. Brad // Neoplasia;Jan/Feb2002, Vol. 4 Issue 1, p68 

    Focuses on the ability of polyamine inhibitors to influence glucocorticoid-induced apoptosis in human lymphoblastic leukemic CEM cells. Effect of synthetic glucocorticoid dexamethasone on ornithine decarboxylase activity, mRNA and protein in CEM cells; Extent and onset of apoptotic cell death...

  • Polyamine levels of human colorectal adenocarcinomas are correlated with tumor stage and grade. Weiss, Thomas S.; Bernhardt, Günther; Buschauer, Armin; Thasler, Wolfgang E.; Dolgner, Doris; Zirngibl, Hubert; Jauch, Karl-Walter // International Journal of Colorectal Disease;Nov2002, Vol. 17 Issue 6, p381 

    Background and aims. Cellular proliferation and differentiation are regulated by polyamines and their rate-limiting enzyme ornithine decarboxylase (ODC), both of which are correlated with tumor growth, but their role in differentiation is less clear. We investigated the correlation of ODC...

  • Overexpression of ornithine decarboxylase increases myogenic potential of H9c2 rat myoblasts. Govoni, Marco; Bonavita, Francesca; Shantz, Lisa M.; Guarnieri, Carlo; Giordano, Emanuele // Amino Acids;Feb2010, Vol. 38 Issue 2, p541 

    Myoblast differentiation into multinuclear myotubes implies the slow-down of their proliferative drive and the expression of myogenin, an early marker of myogenic differentiation. Natural polyamines—such as putrescine, spermidine and spermine—are low molecular weight organic...

  • Plant ornithine decarboxylase is not post-transcriptionally feedback regulated by polyamines but can interact with a cytosolic ribosomal protein S15 polypeptide. Illingworth, Crista; Michael, Anthony // Amino Acids;Feb2012, Vol. 42 Issue 2/3, p519 

    The formation of putrescine by ornithine decarboxylase (ODC) is a key regulatory step in polyamine biosynthesis in metazoa and fungi. Excess polyamines post-transcriptionally induce the synthesis of a unique non-competitive protein inhibitor of ODC, termed antizyme. Binding of antizyme to an ODC...

  • Differential expression of ornithine decarboxylase antizyme inhibitors and antizymes in rodent tissues and human cell lines. Ramos-Molina, Bruno; López-Contreras, Andrés; Cremades, Asunción; Peñafiel, Rafael // Amino Acids;Feb2012, Vol. 42 Issue 2/3, p539 

    Ornithine decarboxylase antizyme inhibitors, AZIN1 and AZIN2, are regulators and homologous proteins of ornithine decarboxylase (ODC), the rate limiting enzyme in the biosynthesis of polyamines. In this study, we have examined by means of real-time RT-PCR the relative abundance of mRNA of the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics