Hypolactasia and Crohn's Disease: A Myth

Park, Richard H. R.; Duncan, Andrew; Russell, Robin I.
June 1990
American Journal of Gastroenterology;Jun1990, Vol. 85 Issue 6, p708
Academic Journal
A retrospective analysis was made of jejunal biopsies performed on 62 patients with Crohn's disease for disaccharidase levels and routine histology. Thirteen patients with irritable bowel syndrome acted as a control group. Two patients with Crohn's disease bad hypolactasia. Two patients bad marginally low sucrase levels, but all patients bad normal maltase levels. Only one patient with irritable bowel syndrome bad hypolactasia with normal histology. There were no significant differences between the two groups. Four patients with Crohn's disease bad abnormal jejunal histology. The prevalence of hypolactasia in patients with Crohn's disease is not increased. Ideally lactase deficiency in patients with Crohn's disease should be confirmed before starting a lactose-free diet which can produce further restrictions on dietary intake.


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