TITLE

Sclerosants for Variceal Sclerotherapy: A Critical Appraisal

AUTHOR(S)
Sarin, S. K.; Kumar, A.
PUB. DATE
June 1990
SOURCE
American Journal of Gastroenterology;Jun1990, Vol. 85 Issue 6, p641
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Endoscopic sclerotherapy is a well-accepted technique for the treatment of variceal bleeding. It is carried out by injecting a sclerosant into or around a varix. Sclerosants are oily or aqueous chemicals which produce sclerosis, depending on their necroinflammatory and thrombotic properties. The safety and efficacy of various sclerosants bas been evaluated in experimental and human studies. However, due to the presence of a large number of variables, conflicting results have been reported. Based primarily on anecdotal experiences, sodium tetradecyl sulfate, ethanolamine oleate, polidocanol, and alcohol appear to be potent and safe sclerosants. There is great need to perform double-blind trials to identify ideal sclerosant(s) with optimum thrombogenic and minimum necroinflammatory properties.
ACCESSION #
16066737

 

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