TITLE

Does Pancreatic Enzyme Supplementation Reduce Pain in Patients with Chronic Pancreatitis: A Meta-Analysis

AUTHOR(S)
Brown, Alphonso; Hughes, Michael; Tenner, Scott; Banks, Peter A.
PUB. DATE
November 1997
SOURCE
American Journal of Gastroenterology;Nov1997, Vol. 92 Issue 11, p2032
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: Pancreatic enzyme therapy is widely used in the treatment of pain in chronic pancreatitis. The aim of our study was to perform a meta-analysis to determine whether pancreatic enzyme supplementation significantly decreases abdominal pain in patients with chronic pancreatitis. Methods: From a MEDLINE search, we identified, evaluated, and subjected to a meta-analysis, six randomized, double-blind, placebo-controlled trials. Important features of data extraction included the method of subject inclusion, definition of disease, enzyme preparation, response to pancreatic enzyme therapy versus placebo, and modality for measuring response. Results: In the meta-analysis, the pooled estimate of the percentage of patients per study who preferred enzymes relative to placebo was 52% (95% confidence interval, 45-60%). A test of homogeneity indicated that there was no statistically significant heterogeneity across studies in the percentage of patients preferring enzymes. Conclusion: Statistical analysis demonstrates no significant benefit of supplemental pancreatic enzyme therapy to relieve pain associated with chronic pancreatitis.
ACCESSION #
16029759

 

Related Articles

  • Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects. Furlan, Andrea D.; Sandoval, Juan A.; Mailis-Gagnon, Angela; Tunks, Eldon // CMAJ: Canadian Medical Association Journal;5/23/2006, Vol. 174 Issue 11, p1589 

    Background: Chronic noncancer pain (CNCP) is a major health problem, for which opioids provide one treatment option. However, evidence is needed about side effects, efficacy, and risk of misuse or addiction. Methods: This meta-analysis was carried out with these objectives: to compare the...

  • Osteoarthritis.  // Current Medical Literature: Rheumatology;2007, Vol. 26 Issue 4, p114 

    A review of two articles about osteoarthritis is presented. It includes "Effect of Chondroitin Sulphate in Symptomatic Knee Osteoarthritis: A Multicenter, Randomised, Double-Blind, Placebo-Controlled Study," by B. Mazières and "Meta-Analysis: Acupuncture for Osteoarthritis of the Knee," by E....

  • Integration of evidence from multiple meta-analyses: a primer on umbrella reviews, treatment networks and multiple treatments meta-analyses. Ioannidis, John P. A. // CMAJ: Canadian Medical Association Journal;10/13/2009, Vol. 181 Issue 8, p488 

    The article focuses on the benefits and limitations of methods that integrate evidence from multiple meta-analyses. It states that umbrella reviews, that offer several treatment comparisons for same diseases, provides a wider analyses of treatments and treatment networks provides comparison...

  • Pancreatic enzyme replacement therapy for pancreatic exocrine insufficiency: When is it indicated, what is the goal and how to do it? Domínguez-Muñoz, J. E. // Advances in Medical Sciences (De Gruyter Open);2011, Vol. 56 Issue 1, p1 

    Pancreatic exocrine insufficiency with steatorrhea is a major consequence of pancreatic diseases (e.g. chronic pancreatitis, cystic fibrosis, severe acute necrotizing pancreatitis, pancreatic cancer), extrapancreatic diseases like celiac disease and Crohn's disease, and gastrointestinal and...

  • Improving Digestion. STRAUS, MARY // Whole Dog Journal;May2012, Vol. 15 Issue 5, p22 

    The article focuses on the benefits of digestive enzyme, prozyme for dogs who find difficult to digest food due to lack of their own enzyme. Topics discussed include benefits of enzymes to older dogs and those who are affected with several disease including acute or chronic pancreatitis,...

  • Treatment of Acute Alcoholic Pancreatitis: The Roles of Cimetidine and Nasogastric Suction. Loiudice, Thomas A.; Lang, Jean; Mehta, Harshad; Banta, Lawrence // American Journal of Gastroenterology;Jul1984, Vol. 79 Issue 7, p553 

    A double-blind prospective controlled study designed to determine the effectiveness of the addition of cimetidine to standard treatment of acute alcoholic pancreatitis and to determine the importance of nasogastric suction in this disorder was undertaken. Forty-five patients were randomized to...

  • Pharmacotherapy for the Prevention of Post-ERCP Pancreatitis. Foster, Erina; Leung, Joseph // American Journal of Gastroenterology;Jan2007, Vol. 102 Issue 1, p52 

    Post-ERCP pancreatitis (PEP) is a potential complication of ERCP. Pharmacotherapy for prevention of PEP aims at reducing basal sphincter pressure and contractility or a decrease in pancreatic secretion to reduce intraductal pressure. Timing and route of administration of drugs are critical to...

  • Correction: Are Treatments More Effective than Placebos? A Systematic Review and Meta-Analysis. Howick, Jeremy; Friedemann, Claire; Tsakok, Maria; Watson, Robert; Tsakok, Teresa; Thomas, Jennifer; Perera, Rafael; Fleming, Susannah; Heneghan, Carl // PLoS ONE;1/15/2016, Vol. 11 Issue 1, p1 

    No abstract available.

  • Conservative interventions provide short-term relief for non-specific neck pain: a systematic review. Leaver, Andrew M.; Refshauge, Kathryn M.; Maher, Christopher G.; McAuley, James H. // Journal of Physiotherapy (Australian Physiotherapy Association);2010, Vol. 56 Issue 2, p73 

    Question: Which interventions for non-specific neck pain are effective in reducing pain or disability? Design: Systematic review with meta-analysis of randomised controlled trials. Participants: Adults with non-specific neck pain. Intervention: All interventions for neck pain that were evaluated...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics