TITLE

Liver Involvement in Addison's Disease

AUTHOR(S)
Olsson, Rolf G.; Lindgren, Anders; Zettergren, Lennart
PUB. DATE
April 1990
SOURCE
American Journal of Gastroenterology;Apr1990, Vol. 85 Issue 4, p435
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Three patients admitted because of slightly increased serum aminotransferases were found to have Addison's disease. A review of 16 other patients with Addison's disease who had serum aminotransferase activity [aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT)] determined prior to treatment revealed one more patient with slightly increased aminotransferase activity that could not be explained by known causes of increased serum aminotransferase levels. In all four of these patients, the enzymes normalized within 1 wk of corticosteroid substitution treatment. Liver biopsy in one patient revealed discrete lymphocytic infiltrates in the portal zones. On the basis of these observations, we recommend that the possibility of Addison's disease should be considered in patients with obscure slight hypertransaminasemia.
ACCESSION #
16018891

 

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