Mechanisms of improved survival from intensive followup in colorectal cancer: a hypothesis

Renehan, A G; Egger, M; Saunders, M P; O'Dwyer, S T
February 2005
British Journal of Cancer;2/14/2005, Vol. 92 Issue 3, p430
Academic Journal
A meta-analysis of six randomised trials demonstrated that intensive followup in colorectal cancer was associated with an absolute reduction in all-cause 5-year mortality of 10%(95%confidence interval (CI): 4-16)-however, only two percent (95%CI: 0-5) was attributable to cure from salvage re-operations. We postulate that other factors, such as increased psychological well-being and/or altered lifestyle, and/or improved treatment of coincidental disease may contribute to the remaining lives saved, and form important future research questions.British Journal of Cancer (2005) 92, 430-433. doi:10.1038/sj.bjc.6602369 www.bjcancer.com Published online 1 February 2005


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