TITLE

N-Arylamine derivatives of 3-hydroxy-4-pyridinones: solution studies and bioevaluation in view of Al-detoxification roles

AUTHOR(S)
Santos, M. Amélia; Gil, Marco; Marques, Sérgio; Gano, Lurdes; Chaves, Sílvia
PUB. DATE
January 2005
SOURCE
Analytical & Bioanalytical Chemistry;Jan2005, Vol. 381 Issue 2, p413
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A study of a series of bifunctional 3-hydroxy-4-pyridinone derivatives, containing side-chains with various alkyl-aryl-amine-amides as extra-functional groups, was conducted to assess the relevance of those groups to the Al-chelating affinity, the lipo-hydrophilic balance of the compounds, and67Ga biodistribution in mice, in view of their potential use as Al-decorporating agents; the results were compared with those for the drug Deferriprone. Their acid-base properties and Al-chelating affinity in aqueous solution were studied by potentiometric techniques. These ligands form very stable tris-chelated Al complexes and the non-chelating extra-groups are only responsible for small differences in the complex stability (?pAl=1.2). At physiological pH the major ligand/complex species have different charges, because of the different extent of protonation of the ligands. The introduction of the different groups induces a well-balanced stepwise-like lipo-hydrophilic character (-0.2
ACCESSION #
16004484

 

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