TITLE

Microsynthesis and electron ionisation mass spectrometric analysis of chemical weapons convention (CWC)-relatedO,O-dialkyl-N,N-dialkylphosphoramidates

AUTHOR(S)
Palit, Meehir; Pardasani, Deepak; Gupta, A. K.; Shakya, Purushottam; Dubey, D. K.
PUB. DATE
January 2005
SOURCE
Analytical & Bioanalytical Chemistry;Jan2005, Vol. 381 Issue 2, p477
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The paper describes microsynthesis and GC/EIMS analysis ofO,O-dialkyl-N,N-dialkylphosphoramidates (DADAPs). DADAPs belong to schedule 2B6 category of chemical weapons convention (CWC), as they are important markers of the chemical warfare agent Tabun and its analogues. The study was undertaken to develop a spectral database of DADAPs for verification of CWC. The reported synthetic strategy can be adopted to prepare several analogues of DADAPs simultaneously and rapidly during official proficiency tests, for the unambiguous identification of analytes within a short period. Based on the EIMS data of more than 60 compounds, fragmentation routes are proposed which explain the formation of most of the characteristic fragment ions. Subtle differences in EIMS of isomeric DADAPs are discussed to facilitate their identification.
ACCESSION #
16004474

 

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