TITLE

Comparison of the analysis of corticosteroids using different techniques

AUTHOR(S)
Pujos, E.; Flament-Waton, M. M.; Paisse, O.; Grenier-Loustalot, M. F.
PUB. DATE
January 2005
SOURCE
Analytical & Bioanalytical Chemistry;Jan2005, Vol. 381 Issue 1, p244
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In this work we have optimized the analysis of 18 human corticosteroids, some endogenous (tetrahydrocortisol, tetrahydrocortisone, cortisol, and cortisone) and others synthetic (betamethasone, budesonide, cortisone acetate, desonide, dexamethasone, dexamethasone acetate, flunisolide, fluocinolone acetonide, halcinonide, methylprednisolone, prednisolone, prednisone, triamcinolone, and triamcinolone acetonide). Three analytical techniques were developed: ELISA, gas chromatography coupled with mass spectrometry (GC-MS), and liquid chromatography coupled with mass spectrometry (LC-MS). Several sample-preparation methods were optimized for each technique and enabled compounds of interest to be extracted from small urine samples (several mL). The results enabled us to assess the possibilities and the sensitivity of each technique for application to doping tests.
ACCESSION #
16004450

 

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