Detection of influenza virus: traditional approaches and development of biosensors

Amano, Yoshihisa; Quan Cheng
January 2005
Analytical & Bioanalytical Chemistry;Jan2005, Vol. 381 Issue 1, p156
Academic Journal
Influenza is an acute respiratory disease caused by the influenza virus. The disease occurs annually, causing fatality in the elderly and children and billions of dollars loss in business and productivity. Traditional viral detection methods include MDCK cell culture, complement fixation, hemagglutinin-inhibition, and recently RT-PCR. Although effective, these methods generally involve labor-intensive laboratory procedures and often require trained personnel to carry them out. The development of biosensor technologies will enable rapid and specific disease diagnosis on-site so that a clinician can quickly determine whether treatment is needed. This paper reviews traditional viral assays and progress in the biosensor development for influenza virus. Recent advances in single-step direct detection using non-labeling techniques such as surface plasmon resonance, quartz-crystal microbalance, and colorimetric functional polymers are discussed.


Related Articles

  • Glycobiology: Surface sensing.  // Nature;1/29/2009, Vol. 457 Issue 7229, p618 

    The article discusses glycan arrays and their use in the identification of cell-surface sugars that influenza pathogens use to bind to a cell. Topics include an overview of research by Hwang and Mullen using microfluidic delivery channels to place glycoproteins on a gold surface and diagnostic...

  • Influenza virus surveillance using surface plasmon resonance. Suenaga, Emi; Mizuno, Hiroshi; Kumar, Penmetcha K. R. // Virulence;8/15/2012, Vol. 3 Issue 5, p464 

    The hemagglutinin (HA) proteins derived from avian influenza viruses bind specifically to the α2-3 sialoglycan (Sia glycan), whereas human-adapted influenza viruses prefer to bind to the α2-6 Sia glycan. A switch of glycan specificity from α2-3 Sia glycan to α2-6 Sia glycan appears...

  • No job too small.  // Nature Materials;Jun2008, Vol. 7 Issue 6, p419 

    The article discusses various reports published within the issue including one on surface plasmon effects and another on successful imaging approach by surface plasmon.

  • Laninamivir Octanoate and Artificial Surfactant Combination Therapy Significantly Increases Survival of Mice Infected with Lethal Influenza H1N1 Virus. Masaya Fukushi; Makoto Yamashita; Tohru Miyoshi-Akiyama; Shuku Kubo; Kenji Yamamoto; Koichiro Kudo; Yi Guan // PLoS ONE;Aug2012, Vol. 7 Issue 8, Special section p1 

    Background: Patients with influenza virus infection can develop severe pneumonia and acute respiratory distress syndrome (ARDS) which have a high mortality. Influenza virus infection is treated worldwide mainly by neuraminidase inhibitors (NAIs). However, monotherapy with NAIs is insufficient...

  • Determination of Binding Potency of Peptidic Inhibitors of Grb2-SH2 by Using the Protein-Captured Biosensor Method. Lung, Feng-Di T.; Wan-Ching Li; Yung-Hsien Chang; Hui-Ming Chen // Protein & Peptide Letters;Aug2008, Vol. 15 Issue 8, p806 

    The growth factor receptor-binding protein 2-Src homology 2 (Grb2-SH2) domain plays an important role in the oncogenic Ras signal transduction pathway, therefore, peptidic inhibitors of the Grb2-SH2 domain has been chosen as our target for the development of antiproliferative agents. The...

  • Plasmonic Sensors Based on Doubly-Deposited Tapered Optical Fibers. González-Cano, Agustín; Navarrete, María-Cruz; Esteban, Óscar; Díaz-Herrera, Natalia // Sensors (14248220);Mar2014, Vol. 14 Issue 3, p4791 

    A review of the surface plasmon resonance (SPR) transducers based on tapered fibers that have been developed in the last years is presented. The devices have proved their good performance (specifically, in terms of sensitivity) and their versatility and they are a very good option to be...

  • 30 Years of Surface Plasmon Resonance (SPR) for Biosensing. Geddes, Chris // Plasmonics;Aug2014, Vol. 9 Issue 4, p727 

    An introduction is presented which discusses various topics presented at a symposium held at the Nanyang Technological University in Singapore from November 5?7, 2013 including fundamentals of surface plasmon optics in biosensing, surface plasmon resonance (SPR) biosensing and plasmon excitation.

  • Real-time monitoring of biomolecular interactions in blood plasma using a surface plasmon resonance biosensor. Špringer, Tomáš; Piliarik, Marek; Homola, Jiří // Analytical & Bioanalytical Chemistry;Nov2010, Vol. 398 Issue 5, p1955 

    We report a novel approach to biosensor-based observations of biomolecular interactions which enables real-time monitoring of biomolecular interactions in complex media. This approach is demonstrated by investigating the interaction between the human chorionic gonadotropin (hCG) and its antibody...

  • On-line determination of 3,5,6-trichloro-2-pyridinol in human urine samples by surface plasmon resonance immunosensing. Mauriz, E.; Calle, A.; Manclús, J. J.; Montoya, A.; Lechuga, L. M. // Analytical & Bioanalytical Chemistry;Apr2007, Vol. 387 Issue 8, p2757 

    An immunochemical method for the analysis of 3,5,6-trichloro-2-pyridinol (TCP), a major urinary metabolite of chlorpyrifos, is developed using a surface plasmon resonance (SPR)-based biosensor. The stability of the assay was assessed by covalently linking the analyte derivative to a thin,...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics