TITLE

Mapping protein-protein interactions by bioinformatics and cross-linking

AUTHOR(S)
Friedhoff, Peter
PUB. DATE
January 2005
SOURCE
Analytical & Bioanalytical Chemistry;Jan2005, Vol. 381 Issue 1, p78
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Discusses the use of bioinformatics and cross-linking in mapping protein-protein interactions. Role of protein-protein interactions in cellular processes; Task of functional proteomics; Methods used for the structural determination of protein-protein complexes.
ACCESSION #
16004424

 

Related Articles

  • Comparison of the Local Concentration of the HU Protein for Particular Regions of Genomic DNA in Escherichia coli Cells in Vivo. Preobrajenskaya, O. V.; Starodubova, E. S.; Karpov, V. L.; Rouviere-Yaniv, J. // Molecular Biology;Jul2005, Vol. 39 Issue 4, p585 

    HU, a nonspecific histone-like DNA-binding protein, is a major component of the bacterial nucleoid. HU is referred to as an accessory factor in forming and maintaining specific DNA conformations in complex DNA-protein assemblies and as a protein involved in DNA compaction. The HU distribution...

  • Literature-curated protein interaction datasets. Cusick, Michael E.; Haiyuan Yu; Smolyar, Alex; Venkatesan, Kavitha; Carvunis, Anne-Ruxandra; Simonis, Nicolas; Rual, Jean-François; Borick, Heather; Braun, Pascal; Dreze, Matija; Vandenhaute, Jean; Galli, Mary; Yazaki, Junshi; Hill, David E.; Ecker, Joseph R.; Roth, Frederick P.; Vidal, Marc // Nature Methods;Jan2009, Vol. 6 Issue 1, p39 

    High-quality datasets are needed to understand how global and local properties of protein-protein interaction, or 'interactome', networks relate to biological mechanisms, and to guide research on individual proteins. In an evaluation of existing curation of protein interaction experiments...

  • Protein—protein interaction and pathway databases, a graphical review. Klingström, Tomas; Plewczynski, Dariusz // Briefings in Bioinformatics;Nov2011, Vol. 12 Issue 6, p702 

    The amount of information regarding protein–protein interactions (PPI) at a proteomic scale is constantly increasing. This is paralleled with an increase of databases making information available. Consequently there are diverse ways of delivering information about not only PPIs but also...

  • Comparison of protein interaction networks reveals species conservation and divergence. Zhi Liang; Meng Xu; Teng, Maikun; Liwen Niu // BMC Bioinformatics;2006, Vol. 7, p457 

    Background: Recent progresses in high-throughput proteomics have provided us with a first chance to characterize protein interaction networks (PINs), but also raised new challenges in interpreting the accumulating data. Results: Motivated by the need of analyzing and interpreting the...

  • Editorial. Gonz�lez-D�az, Humberto // Current Proteomics;Dec2009, Vol. 6 Issue 4, p203 

    In our days, there is an explosion on the use of Topological Indices (TIs) and Connectivity Indices (CIs) described from graph theory to study Complex Networks on a broad spectrum of topics related to Bioinformatics and Proteomics. These topics cover many biomedical fields from Virology,...

  • Towards a Hierarchical Strategy to Explore Multi-Scale IP/MS Data for Protein Complexes. Kutzera, Joachim; Smilde, Age K.; Wilderjans, Tom F.; Hoefsloot, Huub C. J. // PLoS ONE;10/8/2015, Vol. 10 Issue 10, p1 

    Protein interaction in cells can be described at different levels. At a low interaction level, proteins function together in small, stable complexes and at a higher level, in sets of interacting complexes. All interaction levels are crucial for the living organism, and one of the challenges in...

  • Effective Identification of Akt Interacting Proteins by Two-Step Chemical Crosslinking, Co-Immunoprecipitation and Mass Spectrometry. Huang, Bill X.; Kim, Hee-Yong // PLoS ONE;Apr2013, Vol. 8 Issue 4, p1 

    Akt is a critical protein for cell survival and known to interact with various proteins. However, Akt binding partners that modulate or regulate Akt activation have not been fully elucidated. Identification of Akt-interacting proteins has been customarily achieved by co-immunoprecipitation...

  • Protein arrays: Proteomics in multiplex. Melton, Lisa // Nature;5/6/2004, Vol. 429 Issue 6987, p101 

    Focuses on the benefits of protein arrays and protein assays to researches on protein interactions. Challenges to protein mapping; Technological developments in proteomics; Description of various protein array techniques and detection systems; Issues concerning biochip manufacturing; Features of...

  • Differences in protein-protein association networks for lung adenocarcinoma: A retrospective study. Datta, Anisha; Sikdar, Sinjini; Gill, Ryan // Bioinformation;2014, Vol. 10 Issue 10, p647 

    Various methods to determine the connectivity scores between groups of proteins associated with lung adenocarcinoma are examined. Proteins act together to perform a wide range of functions within biological processes. Hence, identification of key proteins and their interactions within protein...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics