TITLE

SELENO IR ŠVINO ĮTAKA KRAUJO δ-AMINOLEVULINO RŪGŠTIES DEHIDRATAZĖS AKTYVUMUI IN VITRO

AUTHOR(S)
Ryselis, Stanislovas; Baranauskienė, Dalia; Abdrachmanovas, Olegas; Stepaniukas, Andrius; Šerėnas, K&ecedil;stutis
PUB. DATE
December 2004
SOURCE
Veterinarija ir Zootechnika;2004, Vol. 28 Issue 50, p18
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The influence of selenide anions (Se2-), lead cations (Pb2+) and the ligande anions – acetate (CH3COO-) on the activity of enzyme δ-aminolevulinic acid dehydratase (δ-ALAD) in vitro was investigated. The analysis was performed in human and animal blood in a several different ways: increasing the concentration of Se2- additives on the base of background Pb2+ and added the fixed concentration of active Pb2+ additive, and increasing the concentration of Pb2+, and in the absence or presence of fixed additive of the Se2- ions. The obtained curves of the consecutive multi-dot dependences showed that the influence of Se2- ions on the δ-ALAD activity in human and bovine blood is analogical. The protective influence of Se2- ions in the presence of Pb2+ additives in human blood is lower than that only background Pb2+ concentrations. The diminutive concentrations of Se2- ions slightly changed the δ-ALAD activity penetrating its maximum, while high concentrations inhibit the activity of enzyme. Therefore the diminutive Pb2+ concentrations steeply reduce the δ-ALAD activity penetrating its minimum, higher ones slightly change the enzyme activity penetrating the maximum, and high concentrations of lead ions inhibit the activity of enzyme. The inhibiting influence of Pb2+ ions on the blood δ-ALAD activity, have been assessed while evaluating the position of inhibition leap in the curve of the consecutive multi-dot dependences, in the presence of Se2- ions is lower than that in case of the absence of Se2- ions in blood. The estimated influence of acetate anions on the activity on δ-aminolevulinic acid dehydratase in dog's blood was moderate.
ACCESSION #
15996187

 

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