TITLE

Cerebral cholesterol granuloma in homozygous familial hypercholesterolemia

AUTHOR(S)
Francis, Gordon A.; Johnson, Royce L.; Findlay, J. Max; Jian Wang; Hegele, Robert A.
PUB. DATE
February 2005
SOURCE
CMAJ: Canadian Medical Association Journal;2/15/2005, Vol. 172 Issue 4, p495
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Familial hypercholesterolemia (FH) is characterized by the accumulation of excess cholesterol in tissues including the artery wall and tendons. We describe a patient with homozygous FH who presented with asymptomatic cholesterol granuloma of the brain. The patient's plasma low-density lipoprotein cholesterol level was remarkably responsive to combination hypolipidemic therapy with statin plus ezetimibe. This case illustrates another potential complication of whole-body cholesterol excess and underscores the differences in phenotype and in response to therapy among patients with FH.
ACCESSION #
15954794

 

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