TITLE

Sexual risk behaviour of Canadian participants in the first efficacy trial of a preventive HIV-1 vaccine

AUTHOR(S)
Lampinen, Thomas M.; Chan, Keith; Remis, Robert S.; Merid, Maraki Fikre; Rusch, Melanie; Vincelette, Jean; Logue, Ken; Popovic, Vladimir; Alary, Michel; Schechter, Martin T.; Hogg, Robert S.
PUB. DATE
February 2005
SOURCE
CMAJ: Canadian Medical Association Journal;2/15/2005, Vol. 172 Issue 4, p479
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Phase I and phase II HIV-1 vaccine trials have revealed increases in risky sexual activity among study subjects during the trials, perhaps because the subjects believe that the vaccine being tested is efficacious; subjects may thus suffer harm from their participation. We evaluated the sexual behaviour of Canadian men who have sex with men (MSM) who participated in the phase III Vax004 trial of an HIV-1 vaccine. Methods: Using self-reports of sexual behaviours during the 6 months before trial entry as a baseline, we determined changes in reported sexual behaviour after 6, 12 and 18 months of participation in the trial. Results: Of 291 HIV-seronegative MSM enrolled from July to October 1999, 260 (89%) completed 18 months of follow-up, 19 (7%) experienced seroconversion, and 12 (4%) did not complete follow-up. Unprotected receptive anal intercourse during the previous 6 months with partners whose HIV-1 serostatus was positive or unknown was reported by 21% of men at enrolment and by 27% at any point during 18 months of follow-up. No increase in this behaviour from baseline was reported by participants, including among men who were motivated to enrol because of expected protection from HIV-1 infection, men who believed they had received the vaccine, men who believed that the vaccine had greater than 50% efficacy, or men who believed that they had received the vaccine and that vaccine efficacy was greater than 50%. Interpretation: MSM can be successfully enrolled in HIV-1 vaccine efficacy trials without evident increases in those sexual behaviours most associated with HIV-1 risk.
ACCESSION #
15954789

 

Related Articles

  • drug therapy in HIV infection. Ree, Hugo // HIV Australia;Apr2003, Vol. 2 Issue 3, p25 

    Presents a roundup of the Sixth International Congress on Drug Therapy in HIV Infection held in Glasgow, Scotland in 2002. Discussion on structured treatment interruptions that were raised with an update by Patrick Yeni from France; Vaccine news; Goal of antiviral therapy.

  • Measuring HIV-1-Specific T Cell Immunity: How Valid Are Current Assays? Patricia D'Souza, M.; Altfeld, Marcus // Journal of Infectious Diseases;2/1/2008, Vol. 197 Issue 3, p337 

    The authors reflect on the validity of the current assays of HIV-1-Specific T Cell Immunity vaccines. The author believes that the development of an effective HIV-1 vaccine to prevent virus transmission or stop the progression of the disease is a major challenge in biomedical research. They also...

  • Determinants of personal demand for an AIDS vaccine in Uganda: contingent valuation survey. Bishai, David; Pariyo, George; Ainsworth, Martha; Hill, Kenneth // Bulletin of the World Health Organization;Sep2004, Vol. 82 Issue 9, p652 

    Objective To assess the factors affecting demand for an HIV/AIDS vaccine among adults in their prime earning and childbearing years and the impact of vaccination on risk behaviour in a high-prevalence, low-income country. Methods A contingent valuation survey of 1677 adults aged 18-60 years was...

  • Meeting Reporter.  // Patient Care;Oct2004, Vol. 38 Issue 10, p17 

    Provides information on the AIDS Vaccine Conference held in 2004. Estimates of the number of HIV infections by 2010; Shift in the direction of AIDS vaccine research; Importance of collaborative efforts to accelerate the progress of promising vaccines.

  • Cognitive Executive Functioning in Relation to HIV Medication Adherence Among Gay, Bisexual, and other Men who have Sex with Men. Solomon, Todd M.; Halkitis, Perry N. // AIDS & Behavior;Jan2008, Vol. 12 Issue 1, p68 

    A longitudinal study of 300 HIV-positive gay, bisexual or non-gay-identified men-who-have-sex-with-men was undertaken to consider patterns relating to HIV medication adherence. The purpose of our analyses was to consider the rate of adherence in relation to both age and executive functioning as...

  • nature insight AIDS. Weiss, Ursula // Nature;4/19/2001, Vol. 410 Issue 6831, p961 

    Introduces the topic of HIV/AIDS for the Nature Insight section of the issue. Worldwide prevalence and spread of AIDS; Need for a vaccine to prevent AIDS and medicine to treat those already infected; Details of the articles in the section, including the mechanisms of AIDS and chemotherapy for AIDS.

  • THE QUEST FOR A PREVENTIVE VACCINE AGAINST HIV/AIDS. Esparza, José // Vaccines: Preventing Disease & Protecting Health;2004, p189 

    Information on the efforts to develop a preventive vaccine against HIV/AIDS in the U.S. from a chapter of the book "Vaccines: Preventing Disease and Protecting Health" is presented. It traces the history of HIV/AIDS. It discusses the challenges associated with the efforts to develop HIV vaccine,...

  • HIV aşısı. Yarpuzlu, Aysegul Akbay // Turkish Journal of Biochemistry / Turk Biyokimya Dergisi;Sep2011, Vol. 36 Issue 3, p273 

    An HIV vaccine is a hypothetical vaccine against HIV, the etiological agent of AIDS. As there is no known cure for AIDS, the search for a vaccine has become part of the struggle against the disease. An HIV vaccine is generally considered as the most likely, and perhaps the only way by which the...

  • The quest for the AIDS vaccine. Tonks, Alison // BMJ: British Medical Journal (International Edition);6/30/2007, Vol. 334 Issue 7608, p1346 

    The article focuses on problems researchers are facing in 2007 when attempting to discover a vaccine for AIDS. Arguments are presented which suggest that finding vaccines for the disease are difficult because HIV is one of the most complex viruses ever identified and is extremely good at evading...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics