Bosanquet, A. G.; Bickerstaffe, R.; Fraser, R.
April 1978
Australian Journal of Experimental Biology & Medical Science;Apr1978, Vol. 56 Issue 2, p157
Academic Journal
The article discusses a new large chylomicron lipoprotein remnant from cholesterol-fed rabbits. For many years rabbits fed cholesterol have been used as models for the study of atherosclerosis. They rapidly become hypercholesterolaemic with a large peak of lipoproteins in the very low density fraction. Suggestions that these cholesterol-rich lipoproteins might represent chylomicron remnants have been confirmed. The articles describes the appearance, on analytical ultracentrifugation, of a second lipoprotein peak, not previously described, within the very low density lipoprotein fraction from rabbits fed cholesterol.


Related Articles

  • Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Björkbacka, Harry; Kunjathoor, Vidya V.; Moore, Kathryn J.; Koehn, Stephanie; Ordija, Christine M.; Lee, Melinda A.; Means, Terry; Halmen, Kristen; Luster, Andrew D.; Golenbock, Douglas T.; Freeman, Mason W. // Nature Medicine;Apr2004, Vol. 10 Issue 4, p416 

    Atherosclerosis, the leading cause of death in developed countries, has been linked to hypercholesterolemia for decades. More recently, atherosclerotic lesion progression has been shown to depend on persistent, chronic inflammation in the artery wall. Although several studies have implicated...

  • The dangers of high cholesterol levels are well known--but low levels may also have hidden risks. Greenhalgh, Trisha // Accountancy;Oct95, Vol. 116 Issue 1226, p62 

    Focuses on health risks posed by both high- and low-levels of cholesterol in the body. Diseases resulting from high levels of lipoproteins; Association of cholesterol-lowering treatments with accidental and premeditated violent death; Debate about cholesterol in the medical press.

  • The Reduction, by Concurrent Triglyceride Feeding, of Hypercholesterolaemia and Experimental Atherosclerosis in the Cholesterol Fed Rabbit. Fraser, R.; Courtice, F. C. // Australian Journal of Experimental Biology & Medical Science;Aug1968, Vol. 46 Issue 4, pP7 

    Describes the effect of concurrent triglyceride feeding in rabbits. Reduction of the serum cholesterol levels and amount of experimental atherosclerosis in the rabbits; Enlargement of chylomicrons of thoracic duct lymph as triglyceride dietary load was increased; Incorporation of the absorbed...

  • Ectopic β-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis. Martinez, Laurent O.; Jacquet, Sébastien; Esteve, Jean-Pierre; Rolland, Corinne; Cabezón, Elena; Champagne, Eric; Pineau, Thierry; Georgeaud, Valérie; Walker, John E.; Tercé, François; Collet, Xavier; Perret, Bertrand; Barbaras, Ronald // Nature;1/2/2003, Vol. 421 Issue 6918, p75 

    The effect of high-density lipoprotein (HDL) in protecting against atherosclerosis is usually attributed to its role in 'reverse cholesterol transport'[SUP1]. In this process, HDL particles mediate the efflux and the transport of cholesterol from peripheral cells to the liver for further...

  • The important role for ßVLDLs binding at the fourth cysteine of first ligand-binding domain in the low-density lipoprotein receptor. Iwasaki, Tadao; Takahashi, Sadao; Ishihara, Mitsuaki; Takahashi, Masafumi; Ikeda, Uichi; Shimada, Kazuyuki; Fujino, Takahiro; Yamamoto, Tokuo; Hattori, Hiroaki; Emi, Mitsuru // Journal of Human Genetics;2004, Vol. 49 Issue 11, p622 

    The low-density lipoprotein (LDL) receptor (LDLR) is a crucial role for binding and uptaking apolipoprotein (apo) B-containing lipoproteins, such as very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and LDL. The defect function of the LDLR causes familial...

  • Use of Cholesterol Measurements in Childhood for the Prediction of Adult Hypercholesterolemia. Lauer, Ronald M.; Clarke, William R. // JAMA: Journal of the American Medical Association;12/19/90, Vol. 264 Issue 23, p3034 

    Focuses on a study which evaluated the validity and utility of screening tests for total cholesterol concentrations in school-age children to predict hypercholesterolemia. Methodology of the study; Adult cholesterol levels for those labeled negative and positive during childhood; Low density...

  • Effectiveness of rosuvastatin versus atorvastatin in reducing lipid levels and achieving low-density- lipoprotein cholesterol goals in a usual care setting. Bullano, Michael F.; Kamat, Siddhesh; Wertz, Debra A.; Borok, Gerald M.; Gandhi, Sanjay K.; McDonough, Kenneth L.; Willey, Vincent J. // American Journal of Health-System Pharmacy;2/1/2007, Vol. 64 Issue 3, p276 

    Purpose. The effectiveness of rosuvastatin versus atorvastatin in reducing lipid levels and achieving low-density-lipoprotein (LDL) cholesterol goals in patients treated in a usual care setting was studied. Methods. Electronic medical and pharmacy administrative claims from a western U.S. health...

  • hypercholesterolaemia. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p394 

    An encyclopedia entry for "hypercholesterolaemia" is presented. It refers to a condition in which there is an excessive concentration of blood cholesterol. This condition is thought to be related to high levels of low density lipoprotein (LDL) in the blood and may be caused by a genetic defect...

  • Co-expression of α′ and β subunits of β-conglycinin in rice seeds and its effect on the accumulation behavior of the expressed proteins. Motoyama, Takayasu; Okumoto, Yutaka; Tanisaka, Takatoshi; Utsumi, Shigeru; Maruyama, Nobuyuki // Transgenic Research;Oct2010, Vol. 19 Issue 5, p819 

    transgenic rice that produces both the α′ and β subunits of β-conglycinin has been developed through the crossing of two types of transgenic rice. Although the accumulation level of the α′ subunit in the α′β-transgenic rice was slightly lower than that in the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics