Are intestinal microbes our friend or foe?

Ito, Hiroaki
January 2005
Journal of Gastroenterology;2005, Vol. 40 Issue 1, p111
Academic Journal
This article focuses on the friendliness of intestinal microbes. Toll-like receptors (TLRs) detect microbial infection and play a crucial role in innate and adaptive immune responses. TLRs are a family of transmembrane receptors homologous to Drosophila Toll protein. They are called pattern-recognition receptors because they recognize pathogen -associated molecular patterns present on diverse microbes. TLRs can induce distinct cellular responses by using different adaptor molecules. The mucosal immune system has been considered to have regulatory, anti-inflammatory mechanisms for tolerating commensal bacteria.


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