Genomics and proteomics

January 2005
Mayo Clinic Guide to Women's Cancers;2005, p31
The article focuses on genomics and proteomics, two important areas of cancer research. Genomics is the study of the human genome--the complete set of approximately 40,000 genes in a human being. The completion of the Human Genome Project was an enormous advance in genomics. Information about particular genes can help identify key molecular targets for cancer diagnosis and treatment. Proteomics aims to evaluate the structure, function and expression of proteins. There are about 40,000 genes, but there may be as many as 10 million proteins. A major goal of proteomics is to diagram the protein wiring pathways that control cell growth and activity.


Related Articles

  • Analysis of Genetic and Epigenetic Mechanisms of Toxicity: Potential Roles of Toxicogenomics and Proteomics in Toxicology. Burchiel, Scott W.; Knall, Cindy M.; Davis II, John W.; Paules, Richard S.; Boggs, Susan E.; Afshari, Cynthia A. // Toxicological Sciences;Feb2001, Vol. 59 Issue 2, p193 

    The article highlighted in this issue is “An Aryl Hydrocarbon Receptor Independent Mechanism of JP-8 Jet Fuel Immunotoxicity in Ah-Responsive and Ah-Nonresponsive Mice” by Andrew C. Dudley, Margie M. Peden-Adams, Jackie EuDaly, Richard S. Pollenz, and Deborah E. Keil (pp....

  • Proteomics.  // Mayo Clinic Health Letter;Mar2006, Vol. 24 Issue 3, p4 

    Discusses the potential use of proteomics as treatment for cancers and various diseases. Information on the Human Genome Project; Background on proteomics; Role of proteins in the cellular level; Questions that researchers hope to answer. INSET: Proteomics and ovarian cancer.

  • Proteomics: biology in the post-genomic era. Brower, Vicki // EMBO Reports;Jul2001, Vol. 2 Issue 7, p558 

    In June 2001, when the Human Genome Project and Celera completed the first maps of the human genome, Francis Collins, head of the government sponsored HGP, warned that only then would the real race begin. Proteomics is more complex by several orders of magnitude than genomics, with no one...

  • In sickness and in health: the importance of translational regulation. Reynolds, P. R. // Archives of Disease in Childhood;May2002, Vol. 86 Issue 5, p322 

    Pediatricians from all disciplines can look forward to important and novel insights into the genetic basis for numerous diseases that affect children and their families. The surprising finding that human genome consists of 30-40000 genes, only slightly larger than that of the plant Arabidopsis...

  • Big genome ? big science?  // Nature Cell Biology;Mar2001, Vol. 3 Issue 3, pE65 

    Editorial. Focuses on the significance of human genome in understanding of human evolution, physiology and disease. Efforts of molecular cell biologists to use human genome for cell functions; Potentials of human genome in scientific discovery; Analysis of computational approaches to deal with...

  • Future Directions in Cancer Research: Impact of the Completion of the Human Genome. Zoon, Kathryn C. // Toxicologic Pathology;Mar/Apr2004 Supplement 1, Vol. 32, p1 

    The sequencing of the human genome will have a major impact on the prevention, diagnosis, treatment, monitoring, and outcome of cancer. Progress will most likely occur in a stepwise fashion with the biggest initial impact in diagnosis and molecular targeting of new medicines. Advances in...

  • Little and large.  // Nature Genetics;Feb2001, Vol. 27 Issue 2, p127 

    Editorial. Comments on the status of the human genome project. Significance to the medical community; Scientific and medical implications of the project; Role of molecular biology in the so-called big science era.

  • A review of bioinformatics education in the UK. Counsell, Damian // Briefings in Bioinformatics;Mar2003, Vol. 4 Issue 1, p7 

    If the completion of the first draft of the human genome represents the coming of age of bioinformatics, then the emergence of bioinformatics as a university degree subject represents its establishment. In this paper bioinformatics as a subject for formal study is discussed, rather than as a...

  • BRCA1 and its toolbox for the maintenance of genome integrity. Huen, Michael S. Y.; Sy, Shirley M. H.; Chen, Junjie // Nature Reviews Molecular Cell Biology;Feb2010, Vol. 11 Issue 2, p138 

    The breast and ovarian cancer type 1 susceptibility protein (BRCA1) has pivotal roles in the maintenance of genome stability. Studies support that BRCA1 exerts its tumour suppression function primarily through its involvement in cell cycle checkpoint control and DNA damage repair. In addition,...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics