Haemocompatibility of paediatric membrane oxygenators with heparin-coated surfaces

Wendel, H.P.; Scheule, A.M.; Eckstein, F.S.; Ziemer, G.
January 1999
Perfusion;1999, Vol. 14 Issue 1, p21
Academic Journal
Extracorporeal circulation (ECC) in paediatric patients with heparin-coated oxygenation systems is rarely investigated. The objective of this study was to evaluate, preclinically, the haemocompatibility of paediatric membrane oxygenators with heparin-coated surfaces. We compared 16 paediatric membrane oxygenators (Minimax, Medtronic) in an in vitro heartlung machine model with fresh human blood. Eight of these oxygenation systems had a covalent heparin coating (Carmeda bioactive surface). After 90 min simulated ECC, the heparin-coated systems showed significantly higher platelet count, lower platelet-factor 4 release, reduced contact activation (factor XIIa and kallikrein), and lower neutrophil elastase levels (p < .


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