TITLE

Similarities in acute phase protein response during hibernation in black bears and major depression in humans: a response to underlying metabolic depression?

AUTHOR(S)
Tsiouris, John A.; Chauhan, Ved P. S.; Sheikh, Ashfaq M.; Chauhan, Abha; Malik, Mazhar; Vaughan, Michael R.
PUB. DATE
September 2004
SOURCE
Canadian Journal of Zoology;Sep2004, Vol. 82 Issue 9, p1468
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This study investigated the effects of hibernation with mild hypothermia and the stress of captivity on levels of six acute-phase proteins (APPs) in serial samples of serum from 11 wild and 6 captive black bears (Ursus americanus Pallas, 1780) during active and hibernating states. We hypothesize that during hibernation with mild hypothermia, bears would show an APP response similar to that observed in major depression. Enzyme-linked immunoabsorbent assay was used to measure alpha2-macroglobulin and C-reactive protein, and a nephelometer to measure alpha-antitrypsin, haptoglobin, ceruloplasmin, and transferrin. Levels of all other proteins except ceruloplasmin were significantly elevated during hibernation in both wild and captive bears at the p < 0.05 to p &l; 0.001 level. Alpha2-macroglobulin and C-reactiveprotein levels were increased in captive versus wild bears in both active and hibernating states at the p <0.01 to p < 0.0001 level. During hibernation with mild hypothermia, black bears do not show immunosuppression, but show an increased APP response similar to that in patients with major depression. This APP response is explained as an adaptive response to the underlying metabolic depression in both conditions. Metabolic depression in hibernating bears is suggested as a natural model for research to explain the neurobiology of depression.
ACCESSION #
15855928

 

Related Articles

  • Acute phase protein concentrations in serum and milk from helthy cows, cows with clinical mastitis and cows with extramammary inflammatory conditions. Nielsen, B. H.; Jacobsen, S.; Andersen, P. H.; Niewold, T. A.; Heegaard, P. M. H. // Veterinary Record: Journal of the British Veterinary Association;3/20/2004, Vol. 154 Issue 12, p361 

    The concentrations of the two acute phase proteins, serum amyloid A and haptoglobin, in serum and milk were compared in 10 cows with clinical mastitis, 11 cows with extramammary inflammatory conditions and 10 clinically healthy control cows. The concentrations of both acute phase proteins were...

  • Clinicopathological findings in sheep from Sardinia showing neurological signs of disease. Ligios, C.; Viglietti, A.; Carta, P.; Dexter, G.; Agrimi, U.; Simmons, M. M. // Veterinary Record: Journal of the British Veterinary Association;3/20/2004, Vol. 154 Issue 12, p365 

    The concentrations of the two acute phase proteins, serum amyloid A and haptoglobin, in serum and milk were compared in 10 cows with clinical mastitis, 11 cows with extramammary inflammatory conditions and 10 clinically healthy control cows. The concentrations of both acute phase proteins were...

  • Characterization of Human Serum Mannan-Binding Protein Promoter1. Naito, Haruna; Ikeda, Atsushi; Hasegawa, Keiji; Oka, Shogo; Uemura, Kazuhide; Kawasaki, Nobuko; Kawasaki, Toshisuke // Journal of Biochemistry;1999, Vol. 126 Issue 6, p1004 

    Serum mannan binding protein (MBP), a mannose/N-acetylglusosamine-specific lectin, is important in innate immunity. In order to elucidate the mechanism underlying the wide intra- and interracial variety in the MBP serum level, we have studied the transcriptional regulation of human MBP. Rapid...

  • Sleepy Bears.  // Weekly Reader - Edition 2;Nov2011, Vol. 81, Special section p3 

    The article emphasizes that the body temperature of black bears in Alaska declines only slightly during hibernation based on a study.

  • PHYLOGEOGRAPHIC PATTERNS WITHIN A METAPOPULATION OF BLACK BEARS (URSUS AMERICANUS) IN THE AMERICAN SOUTHWEST. Onorato, Dave P.; Hellgren, Eric C.; Van Den Bussche, Ronald A.; Doan-Crider, Diana L.; Kie, John G. // Journal of Mammalogy;Feb2004, Vol. 85 Issue 1, p140 

    Natural recolonization by large carnivores has rarely been documented. American black bears (Ursus americanus) recently (1988-present) recolonized portions of their former range in western Texas. We used mtDNA sequence data (n = 144 bears) from 7 populations of southwestern black bears in New...

  • Retinol-Binding Protein, Transthyretin, and C-Reactive Protein in Extremely Low Birth Weight (ELBW) Infants. Ambalavanan, Namasivayam; Ross, A. Catharine; Carlo, Waldemar A. // Journal of Perinatology;Nov2005, Vol. 25 Issue 11, p714 

    BACKGROUND:Vitamin A deficiency reduces retinol binding protein (RBP) but not transthyretin (TTR), while inflammation reduces both RBP and TTR and increases C-reactive protein (CRP), an acute phase reactant.OBJECTIVE:To estimate serum RBP, TTR, and CRP in ELBW infants to test the hypotheses that...

  • Clinical value of lipopolysaccharide-binding protein (LBP) determinations in acute pancreatitis. Rau, Bettina; Steinbach, Gerald; Kr├╝ger, Colin M.; Baumgart, Katja; Schilling, Martin; Beger, Hans G. // Langenbeck's Archives of Surgery;Jul2003, Vol. 388 Issue 3, p181 

    Background. Lipopolysaccharide-binding protein (LBP) is a class 1 acute-phase protein that binds and transfers bacterial lipopolysaccharide (LPS). This study investigated the clinical value of measuring LBP for stratifying biochemical severity in acute pancreatitis by using a recently developed...

  • Recent occurrence of an American black bear in Nebraska. Hoffman, Justin D.; Wilson, Sam; Genoways, Hugh H. // Ursus;2009, Vol. 20 Issue 1, p69 

    We report on a young male, cinnamon-phase American black bear (Ursus americanus) that was collected in northwestern Nebraska on 12 May 2008. This specimen represents the first black bear taken in Nebraska since 1907. Cranial characteristics and mass of the individual indicated a 15-16 month old...

  • The Old Man of the Woods. Smith, Dwight G. // World & I;Jun2000, Vol. 15 Issue 6, p160 

    Deals with the North American black bears. Reason for the near extinction of North American black bears; Facts about the North American black bears; Tips on how to behave in bear country.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics