TITLE

COMMENTARY: Ezetimibe plus simvastatin lowered lipid levels more than simvastatin monotherapy in primary hypercholesterolemia

AUTHOR(S)
Bronson, David L
PUB. DATE
January 2005
SOURCE
ACP Journal Club;Jan/Feb2005, Vol. 142 Issue 1, p16
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article reports that ezetimibe plus simvastatin lowered lipid levels more than simvastatin monotherapy in primary hypercholesterolemia. Ezetimibe is a novel lipid-lowering agent that works by blocking intestinal cholesterol absorption. It is most reassuring to see that the combination of simvastatin with ezetimibe has a similar incidence of adverse effects as simvastatin alone. For patients bothered by musculoskeletal symptoms at high doses of starins or who cannot achieve goal LDL-C levels despite high statin doses, the addition of ezetimibe appears to be a safe and effective option.
ACCESSION #
15851786

 

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