COMMENTARY: Ezetimibe plus simvastatin lowered lipid levels more than simvastatin monotherapy in primary hypercholesterolemia

Bronson, David L
January 2005
ACP Journal Club;Jan/Feb2005, Vol. 142 Issue 1, p16
Academic Journal
The article reports that ezetimibe plus simvastatin lowered lipid levels more than simvastatin monotherapy in primary hypercholesterolemia. Ezetimibe is a novel lipid-lowering agent that works by blocking intestinal cholesterol absorption. It is most reassuring to see that the combination of simvastatin with ezetimibe has a similar incidence of adverse effects as simvastatin alone. For patients bothered by musculoskeletal symptoms at high doses of starins or who cannot achieve goal LDL-C levels despite high statin doses, the addition of ezetimibe appears to be a safe and effective option.


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