COMMENTARY: Esomeprazole was not better than omeprazole for resolving heartburn in endoscopy-negative reflux disease

Chiba, Naoki
January 2005
ACP Journal Club;Jan/Feb2005, Vol. 142 Issue 1, p6
Academic Journal
The article reports that esomeprazole was not better than omeprazole for resolving heartburn in endoscopy-negative reflux disease. If heartburn is predominant, these patients are considered to have gastroesophageal reflux disease (GERD). After endoscopy, these patients can be divided into those with erosive disease and those without. Patients in these studies may have a milder form of GERD or they may have had functional dyspepsia, in which rates of symptom relief with PPIs are known to be lower.


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