TITLE

COMMENTARY: Methylprednisolone caused an increase in death after head injury

AUTHOR(S)
Qushmaq, Ismael; Cook, Deborah
PUB. DATE
January 2005
SOURCE
ACP Journal Club;Jan/Feb2005, Vol. 142 Issue 1, p5
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article reports that methylprednisolone caused an increase in death after head injury. Corticosteroids are used for patients with traumatic head injury to a variable degree worldwide. A meta-analysis of 13 randomized trials in adults with this condition suggested benefit but did not exclude harm. The 2 primary outcomes were all-cause mortality at 2 weeks and death or disability at 6 months. Although the mechanisms mediating increased mortality are unclear, these results are likely to be valid.
ACCESSION #
15851766

 

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