COMMENTARY: Methylprednisolone caused an increase in death after head injury

Qushmaq, Ismael; Cook, Deborah
January 2005
ACP Journal Club;Jan/Feb2005, Vol. 142 Issue 1, p5
Academic Journal
The article reports that methylprednisolone caused an increase in death after head injury. Corticosteroids are used for patients with traumatic head injury to a variable degree worldwide. A meta-analysis of 13 randomized trials in adults with this condition suggested benefit but did not exclude harm. The 2 primary outcomes were all-cause mortality at 2 weeks and death or disability at 6 months. Although the mechanisms mediating increased mortality are unclear, these results are likely to be valid.


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