COMMENTARY: Review: Hormone replacement therapy may reduce the risk for death in younger but not older postmenopausal women

Furberg, Curt D.; Psaty, Bruce M.
January 2005
ACP Journal Club;Jan/Feb2005, Vol. 142 Issue 1, p1
Academic Journal
The article reports that hormone replacement therapy (HRT) may reduce the risk for death in younger but not older postmenopausal women. A benefit for a specific cause of death ought to be accompanied by a benefit, or at least a trend, for cause-specific morbidity. The literature offers no such support. The most likely explanation for this difference by age is a chance subgroup finding in a meta-analysis with low power. The meta-analysis has not provided any plausible evidence that should influence the current guidelines for use of HRT.


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