Comparison of antagonizing potencies of dodecane analogues to isoflurane in goldfish

Kitahara, Yusuke; Tatara, Tsuneo; Iwao, Yasuhide
February 2005
Journal of Anesthesia;2005, Vol. 19 Issue 1, p60
Academic Journal
Discusses a study which examined the contribution of the carboxyl group to the antagonizing potency of fatty acids in vivo through comparing antagonizing potencies to isoflurane in goldfish among terminally substituted dodecane analogues. Materials and methods; Dose-response curves of isoflurane in goldfish; Efficacy of decodecane analogues fatty acid (DoAC) compared to alcohol; Role of a negative charge density of the carboxyl group in antagonization of DoAC to isoflurane.


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