TITLE

Evidence for Accelerated Rates of Glutathione Utilization and Glutathione Depletion in Adolescents With Poorly Controlled Type 1 Diabetes

AUTHOR(S)
Darmaun, Dominique; Smith, Shiela D.; Sweeten, Shawn; Sager, Brenda K.; Welch, Susan; Mauras, Nelly
PUB. DATE
January 2005
SOURCE
Diabetes;Jan2005, Vol. 54 Issue 1, p190
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Depletion of glutathione, an important antioxidant present in red cells, has been reported in type 1 diabetes, but the mechanism of this depletion has not been fully characterized. Glutathione depletion can occur through decreased synthesis, increased utilization, or a combination of both. To address this issue, 5-h infusions of L-[3,3-²]H2]cysteine were performed in 16 diabetic adolescents divided into a well-controlled and a poorly controlled group and in eight healthy nondiabetic teenagers as control subjects (HbA1c 6.3 ± 0.2, 10.5 ± 0.6, and 4.8 ± 0.1%, respectively). Glutathione fractional synthesis rate was determined from ²H2-cysteine incorporation into blood glutathione. We observed that 1) erythrocyte cysteine concentration was 41% lower in poorly controlled patients compared with well-controlled patients (P = 0.009); 2) erythrocyte glutathione concentration was ∼29% and ∼36% lower in well-controlled and poorly controlled patients compared with healthy volunteers; and 3) the fractional synthesis rate of glutathione, although similar in well-controlled and healthy subjects (83 ± 14 vs. 82 ± 11% per day), was substantially higher in the poorly controlled group (141 ± 23% per day, P = 0.038). These findings suggest that in diabetic adolescents, poor control is associated with a significant depletion of blood glutathione and cysteine, due to increased rates of glutathione utilization. This weakened antioxidant defense may play a role in the pathogenesis of diabetes complications. Diabetes 54:190-196, 2005
ACCESSION #
15799283

 

Related Articles

  • Endothelial perturbation in children and adolescents with type 1 diabetes: association with markers of the inflammatory reaction. Romano, Mario; Pomilio, Mariapina; Chiarelli, Francesco; Vigneri, Sergio; Falco, Angela; Davi, Giovanni; Chiesa, Pierluigi Lelli; Romano, M; Pomilio, M; Vigneri, S; Falco, A; Chiesa, P L; Chiarelli, F; Davì, G // Diabetes Care;Sep2001, Vol. 24 Issue 9, p1674 

    Objective: The progression of diabetic angiopathy is, in most cases, unpredictable. The aim of this study was to investigate early events that could influence the development of diabetic angiopathy.Research Design and Methods: Circulating levels of von Willebrand factor...

  • Continued Reduction in the Prevalence of Retinopathy in Adolescents With Type 1 Diabetes. DOWNIE, ELIZABETH; CRAIG, MARIA E.; HING, STEPHEN; CUSUMANO, JANINE; CHAN, ALBERT K. F.; DONAGHUE, KIM C. // Diabetes Care;Nov2011, Vol. 34 Issue 11, p2368 

    OBJECTIVE--To examine trends in microvascular complications in adolescents with type 1 diabetes between 1990 and 2009 in Sydney, Australia. RESEARCH DESIGN AND METHODS--We used analysis of complications in 1,604 adolescents (54% female, aged 12--20 years, median duration 8.6 years), stratified...

  • The study of craniofacial morphology and skeletal maturation in insulin dependent diabetes mellitus (IDDM) or juvenile diabetes. Chandrashekhar, M. Hallolli; Padmini, M. N.; Chandralekha, B.; Parekh, Jaineel // Journal of International Oral Health;2011, Vol. 3 Issue 1, p7 

    Objective: (1)To study the craniofacial morphology of Juvenile diabetes (2) To investigate the effect of Juvenile diabetes on the general growth and skeletal maturation of the affected patients(3)To analyze the pattern of association between craniofacial morphology and skeletal maturation in...

  • Adolescents with Type 1 Diabetes: Depression and Poor Metabolic Control. Stewart, Sunita // Current Medical Literature: Diabetes;2006, Vol. 23 Issue 1, p1 

    The article discusses the effect of depression on the management and complications of Type 1 diabetes in adolescents. A study showed the predictive value of self-reported depressive symptoms on health results in young people with type 1 diabetes up to 2 years later. Type 1 diabetic adolescents...

  • Children and Adolescents with Diabetes: A Physical Educator's Guide. Ruholl, Stacey // Illinois Journal for Health, Physical Education, Recreation & Da;Spring2006, Vol. 57, p41 

    Presents a guide for physical educators to learn more about diabetes in children and adolescents. Information on its types, symptoms, complications and management.

  • Female Children and Adolescents With Type 1 Diabetes Have More Pronounced Early Echocardiographic Signs of Diabetic Cardiomyopathy. Suys, Bert E.; Katier, Nienke; Rooman, Raoul P. A.; Matthys, Dirk; Op De Beeck, Lieve; Du Caju, Mark V. L.; De Wolf, Daniel // Diabetes Care;Aug2004, Vol. 27 Issue 8, p1947 

    OBJECTIVE — This study was designed to assess whether children and adolescents with type 1 diabetes have early echocardiographic signs of subclinical cardiac dysfunction and whether sex, state of metabolic control, and diabetes duration are of influence. RESEARCH DESIGN AND METHODS...

  • Adiponectin as a Marker of Complications in Type I Diabetes. Habeeb, Nevin Mohamed Mamdouh; Youssef, Omneya Ibrahim; Saab, Azza Abdel Rahman; Hadidi, Eman Saleh El // Indian Pediatrics;Apr2012, Vol. 49 Issue 4, p277 

    Objective: To evaluate adiponectin levels in children and adolescents with type I diabetes, and their relationship to long term complications. Design: Cross sectional. Setting: Tertiary referral hospital, Cairo, Egypt. Participants: Thirty children and adolescents with type I diabetes mellitus,...

  • Diabetic retinopathy in young predicted by blood pressure.  // Nursing Standard;10/22/2008, Vol. 23 Issue 7, p16 

    The article presents a study conducted by researchers in Australia, which examines the relationship between blood pressure and the development of early retinopathy in adolescents with type 1 diabetes. Results of the study reveal that systolic and diastolic pressures may serve as predictors of...

  • C-Reactive Protein in Relation to the Development of Microalbuminuria in Type 1 Diabetes. Marcovecchio, M. Loredana; Giannini, Cosimo; Widmer, Barry; Dalton, R. Neil; Martinotti, Stefano; Chiarelli, Francesco; Dunger, David B. // Diabetes Care;May2008, Vol. 31 Issue 5, p974 

    OBJECTIVES -- To perform a longitudinal evaluation of high-sensitivity C-reactive protein (hs-CRP) in young people with type 1 diabetes in relation to the development of microalbuminuria (MA). RESEARCH DESIGN AND METHODS -- hs-CRP was measured in 329 blood samples collected from 49 subjects with...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics