Liver enzyme alteration: a guide for clinicians

Giannini, Edoardo G.; Testa, Roberto; Savarino, Vincenzo
February 2005
CMAJ: Canadian Medical Association Journal;2/1/2005, Vol. 172 Issue 3, p367
Academic Journal
ISOLATED ALTERATIONS OF BIOCHEMICAL MARKERS OF LIVER DAMAGE in a seemingly healthy patient can present a challenge for the clinician. In this review we provide a guide to interpreting alterations to liver enzyme levels. The functional anatomy of the liver and pathophysiology of liver enzyme alteration are briefly reviewed. Using a schematic approach that classifies enzyme alterations as predominantly hepatocellular or predominantly cholestatic, we review abnormal enzymatic activity within the 2 subgroups, the most common causes of enzyme alteration and suggested initial investigations.


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