Coxib medications to be handled with care
- Renal effects of cyclooxygenase inhibitors in volume-depleted dogs. Brooks, David P.; Adams, Jerry; DePalma, P. Dennis; Webb, Edward F.; Palmer, Robert H.; Griswold, Don E. // Inflammopharmacology;2000, Vol. 8 Issue 1, p69
Objective: The objective of this study was to investigate the renal effects of celecoxib, a cyclooxygenase-2 (COX-2) specific nonsteroidal anti-inflammatory drug (NSAID). Subjects and treatment: Six volume-depleted, conscious, chronically instrumented dogs received four treatments using a...
- Celecoxib and rofecoxib. Moore, Paul A.; Hersh, Elliot V. // Journal of the American Dental Association (JADA);Apr2001, Vol. 132 Issue 4, p451
Reports on the development of the nonsteroidal anti-inflammatory drugs (NSAID), celecoxib and rofecoxib, to limit the adverse effects seen after chronic use of NSAID. Cyclo-oxygenase mechanism; Specific cyclo-oxygenase 2 inhibitors; Decrease in the antihypertensive effects of...
- Celecoxib. O'Rourke, Maureen E. // Clinical Journal of Oncology Nursing;May/Jun2000, Vol. 4 Issue 3, p143
Provides information on Celecoxib, a nonsteroidal anti-inflammatory drug and a cyclooxygenase-2-inhibitor. Indications of the drug; Effect of the drug on blood count; Precautions for the drug.
- New restrictions on celecoxib (Celebrex) use and the withdrawal of valdecoxib (Bextra). Cotter, Jill; Wooltorton, Eric // CMAJ: Canadian Medical Association Journal;5/10/2005, Vol. 172 Issue 10, p1299
Presents a study which investigated cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. Degree of inhibition of cyclooxygenase 2 relative to cyclooxygenase 1 for various nonsteroidal anti-inflammatory agents; Advice on the use of celecoxib.
- COX-2 inhibitor drugs. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p201
An encyclopedia entry for "COX-2 inhibitor drugs" is presented. They refer to a group of nonsteroidal anti-inflammatory drugs (NSAIDs) which are less likely to cause stomach irritation. Celecoxib is one example of a COX-2 inhibitor drug.
- CV disorder risks extend beyond COX-2-selectivity of NSAIDs. // Reactions Weekly;9/22/2007, Issue 1170, p3
The article deals with studies on the association of the use of NSAIDs with increased risk of stroke and myocardial infarction (MI), regardless of COX-2-selectivity. The first study estimated the relative risk of thrombotic and haemorrhagic strokes in patients with arthritis who had received...
- Temporal Relationship between Use of NSAIDs, Including Selective COX-2 Inhibitors, and Cardiovascular Risk. Motsko, Stephen P.; Rascati, Karen L.; Busti, Anthony J.; Wilson, James P.; Barner, Jamie C.; Lawson, Kenneth A.; Worchel, Jason // Drug Safety;2006, Vol. 29 Issue 7, p621
BACKGROUND AND OBJECTIVE: The search for NSAIDs with less gastrointestinal toxicity led to the introduction of the selective cyclo-oxygenase-2 (COX-2) inhibitors. However, following their introduction into the market, concerns have developed regarding their safety, particularly their...
- COX-2 Inhibitors Celecoxib and Parecoxib: Valuable Options for Postoperative Pain Management. Gajraj, Noor M. // Current Topics in Medicinal Chemistry;Feb2007, Vol. 7 Issue 3, p235
COX-2 inhibitors are equally as efficacious as the non-selective NSAIDs for the treatment of postoperative pain, but have the advantages of a better gastrointestinal side-effect profile as well as a lack of antiplatelet effects. There have been recent concerns regarding the cardiovascular side...
- Celecoxib Shown Effective in Preventing Colon Polyps. Nelson, Nancy J. // JNCI: Journal of the National Cancer Institute;5/17/2006, Vol. 98 Issue 10, p665
The article reports on the effect of celecoxib on colon polyps. Celecoxib is effective in preventing the development of colon polyps and rectal polyps. The claim is base on two clinical trials. Celecoxib is a cyclooxygenase 2 (COX-2) inhibitor that is in the nonsteroidal anti-inflammatory drugs...