TITLE

Procalcitonin as a prognostic marker in meningococcal disease

AUTHOR(S)
Van der Kaay, D.; De Kleijn, E.; De Rijke, Y.; Hop, W.; De Groot, R.; Hazelzet, J.; Van der Kaay, D C M; De Kleijn, E D; De Rijke, Y B; Hop, W C J; Hazelzet, J A
PUB. DATE
November 2002
SOURCE
Intensive Care Medicine;Nov2002, Vol. 28 Issue 11, p1606
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Objective: To assess the prognostic value of procalcitonin levels during the clinical course of meningococcal disease in children.Design: A retrospective, descriptive study.Setting: University paediatric intensive care unit.Patients: Nine patients with meningococcal sepsis and 55 patients with meningococcal septic shock were included in the study, giving a total of 64.Measurements and Results: Procalcitonin (PCT), C-reactive protein (CRP), cytokines (IL-6, IL-8 and TNF-alpha), plasminogen activator inhibitor-1 (PAI-1) and several routine laboratory parameters were determined and expressed as medians (ranges). PCT levels on hospitalisation were elevated in all children as compared to normal values. Median PCT levels on admission were significantly higher in children with septic shock than in children with sepsis (270 ng/ml (5.7-672.3) versus 64.4 (20.6-283.7); p<0.01). When the patients were categorised to severity using the Pediatric Risk of Mortality (PRISM) score (group 1: <15 points, group 2: 16-30, group 3: >30), the PCT levels were significantly different in the three groups. All markers, with the exception of PCT (p=0.056), were significantly different between survivors and non-survivors. When the duration of petechiae was taken into account, the difference in PCT levels became significant (p=0.04).Conclusions: Procalcitonin levels on admission are related to severity. In the case of a short disease history (duration of petechiae), PCT levels are also related to mortality. Although PCT levels are elevated in all patients, the levels per se do not allow a prediction about survival versus non-survival, this is in contrast to other markers and scores (PRISM).
ACCESSION #
15729777

 

Related Articles

  • The clinical value of procalcitonin in the prediction of infected necrosis in acute pancreatitis. Rau, B.; Steinbach, G.; Baumgart, K.; Gansauge, F.; Grünert, A.; Beger, H. G.; Grünert, A // Intensive Care Medicine;Mar2000 Supplement 2, Vol. 26, pS159 

    Objective: Infection of pancreatic necrosis (IN) has a major impact on management and outcome in acute pancreatitis (AP). Currently, guided fine-needle aspiration (FNA) is the only means for an accurate diagnosis of IN. Procalcitonin (PCT), a 116 amino acid pro-peptide of calcitonin...

  • A brief history of procalcitonin. Bohuon, C. // Intensive Care Medicine;Mar2000 Supplement 2, Vol. 26, pS146 

    Focuses on the brief history of procalcitonin (PCT), an excellent marker for medullary thyroid cancer. Identification of the patients with meningitis and other severe infections; Essential of PCT for standardization of assay; Examination of patients with or without inhalational trauma.

  • Forcaltonin.  // Royal Society of Medicine: Medicines;2002, p256 

    The article presents information on Forcaltonin, a proprietary, prescription-only preparation of the calcitonin, in the form of salcatonin. The drug is used to lower blood levels of calcium when they are abnormally high. It is available in a form for subcutaneous, intramuscular or intravenous...

  • Calcitonin Inhibits SDCP-Induced Osteoclast Apoptosis and Increases Its Efficacy in a Rat Model of Osteoporosis. Yi-Jie Kuo; Fon-Yih Tsuang; Jui-Sheng Sun; Chi-Hung Lin; Chia-Hsien Chen; Jia-Ying Li; Yi-Chian Huang; Wei-Yu Chen; Chin-Bin Yeh; Jia-Fwu Shyu // PLoS ONE;Jul2012, Vol. 7 Issue 7, p1 

    Introduction: Treatment for osteoporosis commonly includes the use of bisphosphonates. Serious side effects of these drugs are caused by the inhibition of bone resorption as a result of osteoclast apoptosis. Treatment using calcitonin along with bisphosphonates overcomes these side-effects in...

  • Plethysmographic Evaluation of the Vascular Effects of Human Calcitonin Gene-Related Peptide in Man. Gennari, Carlo; Nami, Renato; Pecchi, Silvio; De Franco, Vincenzo; Panza, Filomena; Pavese, Giovanni // Angiology;Jun1991, Vol. 42 Issue 6, p462 

    Calcitonin gene-related peptide (CGRP) is a neuropeptide with potent cardiovascular effects that include positive inotropic and chronotropic actions systemic vasodilation, and hypotension in animals and in man. The mechanism of action of CGRP is still, however, not clear, and in particular it is...

  • Calcitonin-Derived Carrier Peptides. Neundorf, I.; Beck-Sickinger, A. G. // Current Pharmaceutical Design;Oct2005, Vol. 11 Issue 28, p3661 

    The rescent discovery of carrier peptides offers new opportunities to translocate several bioactive molecules into the cytoplasm. Previous studies have shown that human calcitonin (hCT) and selected C-terminal sequences translocate in nasal epithelium. Moreover, the hCT(9-32) fragment was found...

  • Calcitonin: Both prophylactic and therapeutic usefulness.  // Geriatrics;Mar1991, Vol. 46 Issue 3, p83 

    The article focuses on prophylactic and therapeutic usefulness of calcitonin. Calcitonin is the "only alternative" to estrogen therapy for the prevention of early post-menopausal bone loss, and is also showing promise in the treatment of established osteoporosis. In a double-blind study, three...

  • Calcitonin Levels Do Not Decrease with Weaning in Chronic Alcoholism. M.C. Vantyghem; T. Danel; S. Marcelli-Tourvieille; J. Moriau; L. Leclerc; C. Cardot-Bauters; C. Docao; B. Carnaille; J.L. Wemeau; M. D'Herbomez // Thyroid;Mar2007, Vol. 17 Issue 3, p213 

    Objective:Alcohol might increase calcitonin but this assertion is mainly based on the acute effect of the drug in small animals and humans. The aim of this study was to investigate the effect of chronic alcoholic intoxication on plasma calcitonin (CT) levels. Design:20 smoking male subjects...

  • Procalcitonin as an acute phase marker. Whicher, John; Bienvenu, Jacques; Monneret2, Guillaume // Annals of Clinical Biochemistry;Sep2001, Vol. 38 Issue 5, p483 

    Procalcitonin is a 14-kDa protein encoded by the Calc-1 gene along with calcitonin and katacalcin. The function and regulation of this protein are quite different from those of the other gene products. Blood concentrations of procalcitonin are increased in systemic inflammation, especially when...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics