Removal of propylene glycol and correction of increased osmolar gap by hemodialysis in a patient on high dose lorazepam infusion therapy

G. Parker, Mark; L. Fraser, Gilles; M. Watson, Donald; R. Riker, Richard
January 2002
Intensive Care Medicine;Jan2002, Vol. 28 Issue 1, p81
Academic Journal
We report a case of successful treatment of propylene glycol toxicity by discontinuation of propylene glycol administration and hemodialysis therapy. A critically ill woman receiving high dose intravenous lorazepam therapy is described. Although propylene glycol toxicity often resolves promptly after discontinuation of the causative parenteral source, renal or liver dysfunction may prolong the sequelae of propylene glycol infusion. Hemodialysis efficiently lowers propylene glycol serum concentrations in a manner analogous to extracorporeal therapy for other small molecular weight alcohol intoxications. Therefore, hemodialysis may be a useful component of therapy for critically ill patients exhibiting propylene glycol toxicity in the context of multiple organ dysfunction.


Related Articles

  • Enhanced Green Fluorescent Protein Expression in Pleurotus ostreatus for In Vivo Analysis of Fungal Laccase Promoters. Amore, Antonella; Honda, Yoichi; Faraco, Vincenza // Applied Biochemistry & Biotechnology;Oct2012, Vol. 168 Issue 4, p761 

    The laccase family of Pleurotus ostreatus has been widely characterized, and studies of the genes coding for laccase isoenzymes in P. ostreatus have so far led to the identification of four different genes and the corresponding cDNAs, poxc, pox1, poxa1b and poxa3. Analyses of P. ostreatus...

  • In Vitro and In Vivo Toxicity Profiling of Ammonium-Based Deep Eutectic Solvents. Hayyan, Maan; Looi, Chung Yeng; Hayyan, Adeeb; Wong, Won Fen; Hashim, Mohd Ali // PLoS ONE;Feb2015, Vol. 10 Issue 2, p1 

    The cytotoxic potential of ammonium-based deep eutectic solvents (DESs) with four hydrogen bond donors, namely glycerine (Gl), ethylene glycol (EG), triethylene glycol (TEG) and urea (U) were investigated. The toxicity of DESs was examined using In Vitro cell lines and In Vivo animal model. IC50...

  • Formulation and Evaluation of Cream of Azadirachta indica leaves extracts on Skin Renewal rate. Wadher, Kamlesh J.; Lakhotia, C. L.; Umekar, M. J. // International Journal of ChemTech Research;2009, Vol. 1 Issue 1, p88 

    Azadirachta indica (Neem) is one of the most popular auspicious and well known tree which is more extensively studied for its pharmaceutical and clinical properties. Three creams containing 0.5 %, 1.0 % and 2.0 % w/w of hydroalcoholic macerate extracts of leaves of neem were prepared. Creams...

  • Selective hydrogenolysis of glycerol to propylene glycol on Cu—ZnO catalysts. Shuai Wang; Haichao Liu // Catalysis Letters;Aug2007, Vol. 117 Issue 1/2, p62 

    Hydrogenolysis of biomass-derived glycerol is an alternative route to sustainable production of propylene glycol. Cu–ZnO catalysts were prepared by coprecipitation with a range of Cu/Zn atomic ratio (0.6–2.0) and examined in glycerol hydrogenolysis to propylene glycol at...

  • MARKETS.  // Chemical Market Reporter;2/7/2005, Vol. 267 Issue 6, p12 

    The article presents information related to the chemical industry in the U.S. The market for ethylene glycol had an up-and-down January 2005 with prices falling off the table early in the month before rebounding by the end. The spot market for methanol was quiet for most of January 2005, with...

  • Catalytic processes and catalyst production at OAO Nizhnekamskneftekhim: State of the art and future prospects. Gil'manov, Kh. Kh. // Theoretical Foundations of Chemical Engineering;Sep2007, Vol. 41 Issue 5, p691 

    The production and use of catalysts at OAO Nizhnekamskneftekhim are analyzed. The problems and prospects of further development of catalysts for the following processes are discussed: production of rubbers (BK, SKEPT, SKI, SKD-N brands), α-olefins, ethylene and propylene glycols, propylene...

  • Repeated Positive Ethylene Glycol Levels by Gas Chromatography. Hilliard, Nicholaus J.; Robinson, C. A.; Hardy, Robert; Daly, Thomas M. // Archives of Pathology & Laboratory Medicine;Jun2004, Vol. 128 Issue 6, pe79 

    The article presents a pathologic quiz case whereby it describes the repeated positive ethylene glycol levels by gas chromatography in order to discuss pathologic diagnosis of central venous line contamination of blood samples by propylene glycol from intravenous lorazepam injections. Ethylene...

  • Sequential kinetic parameter estimation of anaerobic fluidized bed bioreactor using an optimization technique. Seok, Jonghyuk; Komisar, Simeon J. // Biotechnology Letters;Oct2002, Vol. 24 Issue 19, p1579 

    Mathematical model parameters for the methanogenic degradation of propylene glycol were estimated in a sequential manner by means of an optimization technique. Model parameters determined from an initial experimental data set using one bioreactor were then verified with the results from a second...

  • Heterogeneous biofilm activity in a segregated anaerobic fluidized bed bioreactor. Seok, Jonghyuk; Komisar, Simeon J. // Biotechnology Letters;Jul2002, Vol. 24 Issue 13, p1083 

    Bed segregation in a fluidized bed bioreactor profoundly influenced biofilm thickness and microbial activities of the biofilm along the bed height. Bioparticles coated with a thin biofilm, observed at the bottom of the reactor, had a higher specific activity in propylene glycol and n-propanol...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics