Gut luminal lactate release during gradual intestinal ischemia

Tenhunen, Jyrki J.; Jakob, Stephan M.; Takala, Jukka A.
December 2001
Intensive Care Medicine;Dec2001, Vol. 27 Issue 12, p1916
Academic Journal
Objectives: Gut ischemia induced by occlusion of the superior mesenteric artery (SMA) results in release of lactate into the gut lumen. We studied the threshold of SMA flow reduction that leads to increased gut luminal lactate during stepwise reduction in SMA blood flow. Design and setting: A randomized, controlled animal experiment in a university experimental research laboratory. Interventions: Anesthetized, normoventilated, normovolemic domestic pigs were randomized to ischemia (n=7) and sham groups (n=7). SMA blood flow was reduced stepwise at 15-min intervals by 22%, 44%, 66%, and 88% and kept constant thereafter for 60 min. Measurements and results: Jejunal luminal microdialysate lactate and mucosal pCO2 were measured every 15 min. The luminal lactate increased over the upper normal limit of 0.2 mmol/l at a median SMA blood flow of 9.6 ml kg–1 min–1 (range 7.5–23.7). In five of seven animals the increase in luminal lactate was preceded by or accompanied by an increase in the mucosal–arterial pCO2 gradient. Conclusions: There is a threshold of SMA blood flow below which gut luminal lactate increases, indicating mucosal anaerobic metabolism. Measurement of gut luminal lactate by microdialysis can be used to assess the adequacy of gut perfusion and the onset of anaerobic metabolism.


Related Articles

  • Proanthocyanidin Protects Intestine and Remote Organs Against Mesenteric Ischemia/Reperfusion Injury. Sizlan, Ali; Guven, Ahmet; Uysal, Bulent; Yanarates, Omer; Atim, Abdulkadir; Oztas, Emin; Cosar, Ahmet; Korkmaz, Ahmet // World Journal of Surgery;Jul2009, Vol. 33 Issue 7, p1384 

    Intestinal ischemia/reperfusion (IR) induces a systemic inflammatory response and releases harmful substances that may affect the function and integrity of distant organs such as lung, liver, and kidney. We conducted this study to find out if proanthocyanidins (PA) has protective effects against...

  • A prolonged interval between deep intestinal ischemia and anastomotic construction does not impair wound strength in the rat. Posma, Lisanne A. E.; Bleichrodt, Robert P.; Van Goor, Harry; Hendriks, Thijs // International Journal of Colorectal Disease;Dec2007, Vol. 22 Issue 12, p1485 

    Transient intestinal ischemia can reduce anastomotic strength, which poses an increased risk of complications. The objective of this study is to establish if a prolonged interval between profound ischemia and construction of an anastomosis affects anastomotic strength. Male Wistar rats were...

  • Gastric PgCO2 and Pg-aCO2 gap are related to d-lactate and not to l-lactate levels in patients with septic shock. Poeze, Martijn; Solberg, Barbara C. J.; Greve, Jan Willem M.; Ramsay, Graham // Intensive Care Medicine;Nov2003, Vol. 29 Issue 11, p2081 

    Objective. Intestinal ischemia causes an increase in lactate production and gastric intramucosal carbon dioxide partial pressure (PgCO2). However, no linear relationship between systemic l-lactate levels and gastric tonometry during intestinal ischemia has been found, probably since l-lactate is...

  • Bloating and Ischemic Bowel Disease. Thuring, Paul; Mendel, Pete // Running & FitNews;Sep/Oct2009, Vol. 27 Issue 5, p12 

    The article provides an answer to a question about bloating and ischemic bowel disease.

  • Chronic intestinal ischaemia.  // British Medical Journal (Clinical Research Edition);1/17/1981, Vol. 282 Issue 6259, p173 

    Focuses on the diagnosis of chronic intestinal ischaemia. Banality of occlusion of the coelic and mesenteric arteries artery by embolus or thrombus; Clinical manifestations of chronic ischaemia of the small and large bowel; Outcomes resulting from arterial insufficiency of the intestine.

  • Running-Associated Proximal Hemmorrhagic Colitis. Moses, Frank M.; Brewer, Thomas G.; Peura, David A. // Annals of Internal Medicine;Mar88, Vol. 108 Issue 3, p385 

    Presents a case study on running-associated proximal hemorrhagic colitis. Association of intestinal ischemia with intestinal bleeding; Appearance of the midascending colon and the cecum and ileocecal valve in a patient with gastrointestinal bleeding.

  • SÃœTÇÜ SIÄžIRLARDA HEMORAJÄ°K BAÄžIRSAK SENDROMU. Kırbaş, Akın; Özdemir, Haydar // e-Journal of New World Sciences Academy (NWSA);2011, Vol. 6 Issue 2, p10 

    No abstract available.

  • Ginsenoside Rb1 Attenuates Intestinal Ischemia Reperfusion Induced Renal Injury by Activating Nrf2/ARE Pathway. Qian Sun; Qing-Tao Meng; Ying Jiang; Zhong-Yuan Xia // Molecules;Jun2012, Vol. 17 Issue 6, p7195 

    Intestinal ischemia reperfusion (IIR) is a serious clinical condition associated with simultaneous multiple organ dysfunction. The aim of this study was to investigate the effects of ginsenoside Rb1 on IIR induced renal injury in mice. An intestinal ischemia reperfusion mouse model was...

  • Management of spontaneous isolated dissection of the superior mesenteric artery: Case report and literature review. Katsura, Morihiro; Mototake, Hidemitsu; Takara, Hiroaki; Matsushima, Kazuhide // World Journal of Emergency Surgery;2011, Vol. 6 Issue 1, p16 

    Background and method: The aim of this study was to assess retrospectively the clinical presentation, management and outcome of three patients with isolated SMA dissection encountered at Okinawa Prefectural Chubu Hospital, Japan from 2005 to 2006, along with a review of the literature. We follow...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics