Responsiveness to intravenous administration of salbutamol in chronic obstructive pulmonary disease patients with acute respiratory failure

A. Volta, Carlo; Alvisi, Raffaele; Marangoni, Elisabetta; R. Righini, Ermino; Verri, Marco; Ragazzi, Riccardo; Alvisi, Valentina; Ferri, Enrico; Milic-Emili, Joseph
December 2001
Intensive Care Medicine;Dec2001, Vol. 27 Issue 12, p1949
Academic Journal
Objective: In chronic obstructive pulmonary disease (COPD) patients with acute respiratory failure (ARF), bronchodilating agents administered by inhalation have, in general, little effect on dynamic hyperinflation and concurrent static intrinsic positive end-expiratory pressure (PEEPi,st). Since in COPD the severely obstructed segments of the lung may not be reached by inhaled medication, we reasoned that drug efficiency may be enhanced by intravenous administration of the agent. Design: Physiological study. Setting: Two four-bed surgical-medical ICUs of a university hospital. Patients: Fourteen COPD patients were studied within 36 h from the onset of ARF. Measurements and results: Static compliance (Cst,rs), minimal (Rmin,rs) and additional (ΔRrs) resistance of the respiratory system, and PEEPi,st were measured before and after intravenous administration of salbutamol. All patients had limitation of air flow before and after salbutamol administration. On average, after salbutamol there was a small, though significant, decrease in Rmin,rs (-9%), ΔRrs (-12%) and PEEPi,st (-8%). Conclusion: The changes in resistance and PEEPi,st after intravenous administration of salbutamol were too small to be of clinical significance.


Related Articles

  • Noninvasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease: Implications of Different Meta-Analytic Strategies. Peter, John V.; Moran, John L. // Annals of Internal Medicine;9/7/2004, Vol. 141 Issue 5, pW-78 

    This article presents a case study related to chronic obstructive pulmonary disease (COPD). Recent meta-analyses have examined the role of noninvasive ventilation in acute exacerbations of COPD. The objective of the study is to assess the use of different analytic strategies in interpreting the...

  • Surfactant protein B intron 4 variation in German patients with COPD and acute respiratory failure. Seifart, Carola; Plagens, Alexandra; Brödje, Dörte; Müller, Bernd; von Wichert, Peter; Floros, Joanna // Disease Markers;2002, Vol. 18 Issue 3, p129 

    Chronic obstructive pulmonary disease (COPD) is a major health problem. Genetic factors that contribute to the disease have been postulated. The pulmonary surfactant protein B (SP-B), which is essential for normal lung function, is considered as a candidate gene for COPD in this case-control...

  • Noninvasive Ventilation for Acute Respiratory Failure. Hess, Dean R. // Respiratory Care;Jun2013, Vol. 58 Issue 6, p950 

    Noninvasive ventilation (NIV) for acute respiratory failure has gained much academic and clinical interest. Despite this, NIV is underutilized. The evidence strongly supports its use in patients presenting with an exacerbation of COPD and in patients with acute cardiogenic pulmonary edema. As...

  • Pulmonary embolism in acute COPD exacerbations.  // OB/GYN Clinical Alert;Jun2009 Clinical Briefs in Primary, pI1 

    The article offers an update on the arising mortality rate of chronic obstructive pulmonary disease (COPD). It notes that COPD is the 4th most common cause of death in the U.S. where majority of its deaths occur during an acute (COPD) exacerbation. It mentions several signs and symptoms that...

  • Varying Leaks: A Challenge for Modern Ventilators? Vignaux, Laurence; Piquilloud, Lise // Respiratory Care;Dec2013, Vol. 58 Issue 12, p2194 

    The article focuses on the need to improve modern ventilators to prevent leaks. It states that severe asynchrony suffered by patients because of delays in delivered pressurization, could increase incidence of leaks which in turn affect the quality of ventilators. It argues on the need to address...

  • Salbutamol.  // Reactions Weekly;9/29/2007, Issue 1171, p24 

    The article presents a case study of a 41-year-old man, who had a 40 pack/year smoking history and a 3-year history of asthma, experienced bronchoconstriction following inhalation of salbutamol for asthma exacerbation. After receiving methylprednisolone and formoterol, he felt breathless and...

  • Noninvasive respiratory support for acute respiratory failure—high flow nasal cannula oxygen or non-invasive ventilation? Curley, Gerard F.; Laffy, John G.; Haibo Zhang; Slutsky, Arthur S. // Journal of Thoracic Disease;Jul2015, Vol. 7 Issue 7, p1092 

    No abstract available.

  • Guidelines for noninvasive ventilation in acute respiratory failure. Chawla, Rajesh; Chaudhry, Dhruva; Kansal, Sudha; Khilnani, G. C.; Mani, R. K.; Nasa, Prashant; Prayag, Shirish; Ramakrishnan, N.; Sharma, Rakesh; Sidhu, U. S.; Suri, J. C. // Indian Journal of Critical Care Medicine;Mar2013 Supplement, p42 

    The article discusses the application of non-invasive ventilation (NIV) in acute respiratory failure. It mentions that testing the NIV in patients with neuromuscular disease and chest wall deformity must be done when they present in acute -on-chronic respiratory failure. It adds that the result...

  • Quick Review: ARDS. Fujii, Tisha K.; Phillips, Bradley J. // Internet Journal of Pulmonary Medicine;2003, Vol. 3 Issue 1, p9 

    This article reviews briefly the main points of Adult Respiratory Distress Syndrome (ARDS). Lung Injury can be divided into Acute Lung Injury (ALI) and ARDS.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics