Comparison of invasive and noninvasive measurements of indocyanine green plasma disappearance rate in critically ill patients with mechanical ventilation and stable hemodynamics

Sakka, Samir G.; Reinhart, Konrad; Meier-Hellmann, Andreas
October 2000
Intensive Care Medicine;Oct2000, Vol. 26 Issue 10, p1553
Academic Journal
Objectives: We studied the correlation between invasive (aortic fiberoptic) and noninvasive (transcutaneous sensor) measurements of indocyanine green (ICG) plasma disappearance rate (PDR) in critically ill patients. Design and setting: Prospective clinical study in a surgical intensive care unit of a university hospital. Patients: 16 critically ill patients with adult respiratory distress syndrome (n=8), sepsis/septic shock (n=6), subarachnoid hemorrhage (n=1), or severe head injury (n=1). Measurements and results: We analyzed 16 pairs of simultaneous ICG PDR measurements. All patients were deeply sedated and mechanically ventilated. Each patient received a 4-F aortic catheter with an integrated fiberoptic and thermistor connected to a computer system for automatic calculation of invasive ICG PDR (PDRINV). An ICG sensor was also attached to the nose wing and connected to a DDG2001 analyzer for noninvasive measurement (PDRNINV). Linear regression analysis revealed PDRNINV=0.98 PDRINV+0.11%/min (r=0.94, p<0.0001) with a mean bias of 0.2±2.0%/min. Conclusion: Noninvasive measurements of ICG PDR are very highly correlated with values derived from an invasive fiberoptic-based reference technique.


Related Articles

  • Flexible fiberoptic bronchoscopy and remifentanil target-controlled infusion in ICU: a preliminary study. Chalumeau-Lemoine, Ludivine; Stoclin, Annabelle; Billard, Valérie; Laplanche, Agnès; Raynard, Bruno; Blot, François // Intensive Care Medicine;Jan2013, Vol. 39 Issue 1, p53 

    Purpose: Flexible fiberoptic bronchoscopy (FFB) is a major diagnostic tool commonly used in intensive care unit (ICU). However, it generates discomfort and pain and can worsen respiratory and/or hemodynamic condition of critically ill patients. Remifentanil is an ultrashort-acting opioid drug...

  • A pilot study on safety and clinical utility of a single-use 72-hour indwelling transesophageal echocardiography probe. Vieillard-Baron, Antoine; Slama, Michel; Mayo, Paul; Charron, Cyril; Amiel, Jean-Bernard; Esterez, Cédric; Leleu, François; Repesse, Xavier; Vignon, Philippe // Intensive Care Medicine;Apr2013, Vol. 39 Issue 4, p629 

    Purpose: To evaluate the hemodynamic monitoring capability and safety of a single-use miniaturized transesophageal echocardiography (TEE) probe left in place in ventilated critically ill patients. Methods: The probe was inserted in 94 patients and designed to be left in place for up to 72 h....

  • Gradual sucrose gastric loading test: A method for the prediction of nonsuccess gastric enteral feeding in critically ill surgical patients. Kaweesak Chittawatanarat; Suun Sathornviriyapong; Yaowalak Polbhakdee // Indian Journal of Critical Care Medicine;Feb2015, Vol. 19 Issue 2, p92 

    Background and Aims: Intolerance of gastric enteral feeding (GEN) commonly occurs in surgical Intensive Care Unit (SICU). A liquid containing sugar could prolong gastric emptying time. This study was to propose a method for prediction of nonsuccess GEN using gastric volume after loading (GVAL)...

  • Respiratory variations in the arterial pressure during mechanical ventilation reflect volume status and fluid responsiveness. Perel, Azriel; Pizov, Reuven; Cotev, Shamay // Intensive Care Medicine;Jun2014, Vol. 40 Issue 6, p798 

    Optimal fluid management is one of the main challenges in the care of the critically ill. However, the physiological parameters that are commonly monitored and used to guide fluid management are often inadequate and even misleading. From 1987 to 1989 we published four experimental studies which...

  • Ventricular interdependence: how does it impact on hemodynamic evaluation in clinical practice? Jardin, François // Intensive Care Medicine;Mar2003, Vol. 29 Issue 3, p361 

    Studies the influence of ventricular interdependence on hemodynamic evaluation in clinical practice by researchers from France. Sensitivity and accuracy of Doppler examination in measuring mitral flow velocity; Association of left ventricle (LV) impaired relaxation with right ventricle (RV)...


    Objective: To review all obstetric admissions to ICU, risk factors for obstetric admissions and their outcomes. Study Design: A Descriptive case series study Place and Duration: Department of Obstetrics & Gynaecology Unit-I in collaboration with General Intensive Care unit at Liaquat University...

  • A Case of Constitutional Indocyanine Green Excretory Defect with Abnormal Retention of Sulfobromophthalein: A New Functional Disorder? Nakamuta, Makoto; Katsuda, Yousuke; Sakamoto, Shigeru; Nawata, Hajime // American Journal of Gastroenterology;Jul1992, Vol. 87 Issue 7, p930 

    Presents a letter to the editor regarding constitutional indocyanine green (ICG) excretory defect, an idiopathic disorder characterized by marked retention of ICG.

  • Persistence of Retinal Indocyanine Green Dye Following Vitreous Surgery. Nakamura, Hideo; Hayakawa, Kazuhisa; Imaizumi, Ayako; Sakai, Miyako; Sawaguchi, Shoichi // Ophthalmic Surgery, Lasers & Imaging;Jan/Feb2005, Vol. 36 Issue 1, p37 

    BACKGROUND AND OBJECTIVE: To investigate the duration of postoperative persistence of indocyanine green (ICG) dye used during vitreous surgery. PATIENTS AND METHODS: Thirty-three patients (34 eyes) underwent macular surgery with removal of the internal limiting membrane (ILM) or epiretinal...

  • Indocyanine Green Angiography in High Myopia. Axer-Siegel, Ruth; Cotlear, Daniel; Priel, Ethan; Rosenblatt, Irit; Snir, Moshe; Weinberger, Dov // Ophthalmic Surgery, Lasers & Imaging;Mar/Apr2004, Vol. 35 Issue 2, p139 

    BACKGROUND AND OBJECTIVE: To evaluate indocyanine green imaging of choroidal changes in pathologic myopia and to compare it with fluorescein angiography. PATIENTS AND METHODS: The angiograms of all consecutive patients with pathologic myopia photographed with confocal indocyanine green...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics