TITLE

Polymorphonuclear neutrophil activation during the acute respiratory distress syndrome

AUTHOR(S)
Chollet-Martin, S.
PUB. DATE
October 2000
SOURCE
Intensive Care Medicine;Oct2000, Vol. 26 Issue 10, p1575
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Studies polymorphonuclear neutrophil (PMN) activation during the acute respiratory distress syndrome by researchers from Paris, France. Skepticism's among the scientific community over limitations of the clinically based definitions; Recommendations for a more mechanistic definitions based in inflammatory criteria particularly related to pulmonary polymorphonuclear neutrophil recruitment and activation; Role of PMN on the induction of a series of events that culminate in parenchymal injury.
ACCESSION #
15729168

 

Related Articles

  • The systemic inflammatory response syndrome. Meeran, H.; Messent, M. // Trauma;Apr2001, Vol. 3 Issue 2, p89 

    The systemic inflammatory response syndrome (SIRS) describes the clinical presentation of patients with systemic activation of the inflammatory response from any underlying cause. SIRS is a common problem in acute medical and surgical practice and an important cause of morbidity and mortality....

  • New Potential Targets to Modulate Neutrophil Function in Inflammation. Burgos, R. A.; Hidalgo, M. A.; Figueroa, C. D.; Conejeros, I.; Hancke, J. L. // Mini Reviews in Medicinal Chemistry;Feb2009, Vol. 9 Issue 2, p153 

    The importance of neutrophils in human disease such as rheumatoid arthritis, asthma, adult respiratory distress syndrome, and COPD has prompted the search for drugs capable to slow down neutrophil-dependent inflammation, without interference with innate immune responses. In this review, we...

  • CXCR2 in Acute Lung Injury. Konrad, F. M.; Reutershan, J. // Mediators of Inflammation;2012, Vol. 2012, p1 

    In pulmonary inflammation, recruitment of circulating polymorphonuclear leukocytes is essential for host defense and initiates the following specific immune response. One pathological hallmark of acute lung injury and acute respiratory distress syndrome is the uncontrolled transmigration of...

  • Neutrophils from critically ill septic patients mediate profound loss of endothelial barrier integrity. Fox, Elizabeth D.; Heffernan, Daithi S.; Cioffi, William G.; Reichner, Jonathan S. // Critical Care;2013, Vol. 17 Issue 5, p1 

    Introduction Sepsis is characterized by systemic immune activation and neutrophil-mediated endothelial barrier integrity compromise, contributing to end-organ dysfunction. Studies evaluating endothelial barrier dysfunction induced by neutrophils from septic patients are lacking, despite its...

  • Inflammatory Response Goes Unchecked in ARDS.  // Pulmonary Reviews;Sep2007, Vol. 12 Issue 9, p24 

    The article discusses research being done on the inflammatory response in acute respiratory distress syndrome (ARDS). It references a study by Kurt Bachmaier and colleagues published in the August 2007 issue of "Nature Medicine." It describes how the E3 ubiquitin ligase Cblb protein modulates...

  • The quorum-sensing molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) enhances the host defence by activating human polymorphonuclear neutrophils (PMN). Wagner, Christof; Zimmermann, Sabine; Brenner-Weiss, Gerald; Hug, Friedrike; Prior, Birgit; Obst, Ursula; Hänsch, Gertrud Maria // Analytical & Bioanalytical Chemistry;Jan2007, Vol. 387 Issue 2, p481 

    The P. aeruginosa quorum-sensing molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) interacts not only with bacteria, but also with mammalian cells, among others with those of the immune defence system. We focussed on the possible interaction of 3OC12-HSL with human polymorphonuclear...

  • HDACi: molecular mechanisms and therapeutic implications in the innate immune system. Suliman, Bandar Ali; Xu, Dakang; Williams, Bryan RG // Immunology & Cell Biology;Jan2012, Vol. 90 Issue 1, p23 

    Histone deacetylase inhibitors (HDACi) are an emerging class of novel anti-cancer drugs that cause growth arrest, differentiation and apoptosis of tumor cells. In addition, many advances have been made in understanding the immunoregulation of Toll-like receptors, NOD-like receptors and...

  • The role of neutrophil apoptosis in the resolution of acute lung injury in newborn infants. Kotecha S; Mildner R J; Prince L R; Vyas J R; Currie A E; Lawson R A; Whyte M K B // Thorax;Nov2003, Vol. 58 Issue 11, p961 

    BACKGROUND: The persistent airway neutrophilia observed in chronic lung disease of prematurity (CLD) may reflect inappropriate suppression of neutrophil apoptosis. METHODS: 134 bronchoalveolar lavage (BAL) samples were obtained from 32 infants requiring mechanical ventilation for respiratory...

  • Infection risk puts the brakes on Canada's biomedical research. Clarke, Tom // Nature;4/17/2003, Vol. 422 Issue 6933, p652 

    Reports on the impact of epidemic of severe acute respiratory syndrome on the biomedical research in Canada. Steps taken to prevent the disease.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics