The initial distribution volume of glucose rather than indocyanine green derived plasma volume is correlated with cardiac output following major surgery

Ishihara, Hironori; Suzuki, Akiko; Okawa, Hirobumi; Sakai, Ichiro; Tsubo, Toshihito; Matsuki, Akitomo
October 2000
Intensive Care Medicine;Oct2000, Vol. 26 Issue 10, p1441
Academic Journal
Objectives: To determine whether the initial distribution volume of glucose (IDVG) rather than plasma volume or blood volume is correlated better with cardiac output during the 4 days following major surgery. Design and setting: Prospective clinical investigation in the general intensive care unit of a university hospital. Patients and methods: 31 consecutive patients who underwent radical surgery for esophageal carcinoma were enrolled. Continuous thermodilution cardiac output monitor was placed in the operating room. Indocyanine green (ICG; 25 mg) and glucose (5 g) were administered simultaneously to calculate IDVG and plasma volume determined using the ICG dilution method. Blood volume was also calculated from plasma volume ICG and hematocrit. Those volumes were measured on admission to the ICU and daily on the first 3 postoperative days. The relationships between each volume and cardiac index (CI), and between routine clinical variables and CI were evaluated. Results: IDVG had a linear correlation with CI in the early postoperative days (r=0.71, n=124, p<0.000001). Measurements of neither the plasma volume nor the blood volume yielded a better correlation with CI than did IDVG (r=0.45, n=124, p<0.000001, and r=0.23, n=124, p<0.01, respectively). No correlation was found between pulmonary artery wedge pressure and CI or between central venous pressure and CI. Conclusions: Our results indicate that IDVG rather than intravascular volume is correlated with cardiac output. We suggest that IDVG has potential as an alternative indicator of cardiac preload following major surgery.


Related Articles

  • Initial distribution volume of glucose as noninvasive indicator of cardiac preload: comparison with intrathoracic blood volume. Gabbanelli, Vincenzo; Pantanetti, Simona; Donati, Abele; Montozzi, Alessandra; Carbini, Cristiana; Pelaia, Paolo // Intensive Care Medicine;Nov2004, Vol. 30 Issue 11, p2067 

    Objective: To analyze the correlation between initial distribution volume of glucose (IDVGI) and intrathoracic blood volume measured by single indicator dilution technique. Design and setting: Prospective clinical study conducted in the in- tensive care unit of a university hospital. Patients...

  • Journal of Clinical Monitoring and Computing 2015 end of year summary: cardiovascular and hemodynamic monitoring. Bendjelid, Karim; Rex, Steffen; Scheeren, Thomas; Saugel, Bernd // Journal of Clinical Monitoring & Computing;Apr2016, Vol. 30 Issue 2, p129 

    Hemodynamic monitoring is essential in critically ill patients. In this regard, the Journal of Clinical Monitoring and Computing (JCMC) has become an ideal platform for publishing cardiovascular and hemodynamic monitoring-related research, as reflected by an increasing number of articles related...

  • High-dose glucose-insulin-potassium has hemodynamic benefits and can improve cardiac remodeling in acute myocardial infarction treated with primary percutaneous coronary intervention: From a randomized controlled study. Yanhui Li; Lin Zhang; Lei Zhang; Haiyong Zhang; Nianzhong Zhang; Zhongsu Yang; Mingming Gao; Xinchun Yang; Liang Cui // Journal of Cardiovascular Disease Research;Jul-Sep2010, Vol. 1 Issue 3, p104 

    Objective: To evaluate the effects of high-dose glucose-insulin-potassium (GIK) solution on hemodynamics and cardiac remodeling in patients with acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention (PCI). Patients and Methods: We observed the changes in the...

  • REFLEX CARDIOVASCULAR RESPONSES TO SIMULATED DIVING. Whayne Jr., Thomas F.; Smith, N. Ty; Eger, Edmond I.; Stoelting, Robert K.; Whitcher, Charles E. // Angiology;Sep1972, Vol. 23 Issue 8, p500 

    Two techniques have been used to study further the diving reflex in man using eight male volunteer subjects. First is a method which allows diving to be simulated by a cold wet cloth placed on the face of an apneic subject. Second is a ballistocardiogram-analog computer system which permits a...

  • Evaluation of cardiac output from a tidally ventilated homogeneous lung model. Benallal, Habib; Beck, Kenneth C.; Johnson, Bruce D.; Busso, Thierry // European Journal of Applied Physiology;Oct2005, Vol. 95 Issue 2/3, p153 

    We used the direct Fick measurements to validate a method for estimating cardiac output by iteratively fitting $$\ifmmode\expandafter\dot\else\expandafter\.\fi{\hbox{V}}_{{{\text{CO}}_{2} }}$$ at the mouth to lung model values. This model was run using a series of 50, 30 and 10 breaths to test...

  • Physiological Responses to Exercise at Altitude: An Update. Mazzeo, Robert S. // Sports Medicine;2008, Vol. 38 Issue 1, p1 

    Studies performed over the past decade have yielded new information related to the physiological and metabolic adjustments made in response to both shortand long-term high-altitude exposure. These investigations have examined the potential mechanisms responsible for the alterations observed in...

  • Plasma matrix metalloproteinases, low density lipoprotein oxidisability and soluble adhesion molecules after a glucose load in Type 2 diabetes. Sampson, Mike; Davies, Isabel; Gavrilovic, Jelena; Sussams, Brendan; Brown, Jackie; Astley, Sian; Hughes, David A. // Cardiovascular Diabetology;2004, Vol. 3, p7 

    Background: Acute hyperglycaemia is an independent cardiovascular risk factor in Type 2 diabetes which may be mediated through increased oxidative damage to plasma low density lipoprotein, and in vitro, high glucose concentrations promote proatherogenic adhesion molecule expression and matrix...

  • Blood flow is an important determinant of forearm glucose uptake following a mixed meal. Fugmann, A.; Sarabi, M.; Karlström, B.; Berne, C.; Lithell, H.; Lind, L. // Acta Diabetologica;Sep2003, Vol. 40 Issue 3, p113 

    Insulin-mediated vasodilation has been suggested to be of importance for glucose uptake during normoglycemic hyperinsulinemia. If this also is valid after an ordinary mixed meal remains to be evaluated. Forearm blood flow (FBF) and forearm glucose uptake change (evaluated by venous occlusion...

  • Glomerular hemodynamic alterations during acute hyperinsulinemia in normal and diabetic rats. Tucker, Bryan J.; Anderson, Christen M.; Thies, R. Scott; Collins, Rose C.; Blantz, Roland C. // Kidney International;Nov1992, Vol. 42 Issue 5, p1160 

    Treatment of insulin dependent diabetes invariably requires exogenous insulin to control blood glucose. Insulin treatment, independent of other factors associated with insulin dependent diabetes, may induce changes that affect glomerular function. Due to exogenous delivery of insulin in insulin...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics