TITLE

Effects of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green in human septic shock

AUTHOR(S)
Lehmann, Christian; Taymoorian, Kasra; Wauer, Helmar; Krausch, Dietmar; Birnbaum, Jürgen; Kox, Wolfgang J.
PUB. DATE
October 2000
SOURCE
Intensive Care Medicine;Oct2000, Vol. 26 Issue 10, p1557
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: To evaluate the effect of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green (PDR) in patients with septic shock. Design and setting: A prospective clinical study in a university hospital intensive care unit. Patients and interventions: 20 patients in septic shock. Patients received iloprost infusion (1 ng/kg per minute) for 24 h. Measurements and results: PDR was determined by a femoral arterial fiberoptic catheter before, 1, 6, and 24 h after start and 1 h after end of iloprost infusion. PDR increased significantly 24 h after start of iloprost infusion (baseline: 13.9±1.7% vs. 18.6±2.2%/min) and decreased 1 h after end of infusion (13.7±1.7%/min; p<0.002). There was no change in pHi, cardiac index, mean arterial pressure, heart rate, central venous pressure, or intrathoracic blood volume index. Conclusion: Administration of the stable prostacyclin analogue iloprost significantly increases PDR, indicating improvement in liver function.
ACCESSION #
15729157

 

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