Severe regimen-related toxicity occurring in a patient with XYY syndrome receiving allogeneic peripheral blood stem cell transplantation

Shibata, S.; Kami, M.; Kishi, Y.; Hamaki, T.; Ueyama, J.-i.; Miyakoshi, S.; Morinaga, S.-i.; Hirabayashi, N.; Kanda, Y.; Mutou, Y.
July 2002
Annals of Hematology;Jun2002, Vol. 81 Issue 7, p407
Academic Journal
A 23-year-old man with chronic myelocytic leukemia (CML) in the first chronic phase underwent allogeneic peripheral blood stem cell transplantation (PBSCT) from his HLA-identical sibling. Pretransplant evaluations showed that he had a low risk of transplantation-related mortality and that the interval between the diagnosis of CML and PBSCT was only 6 months. However, he developed a variety of complications, including acute renal failure requiring hemodialysis, severe hepatic damage, hemorrhagic cystitis, and gastrointestinal hemorrhage leading to hypovolemic shock. Pathological examination of the colonic mucosa showed vascular endothelial damage and thrombotic lesions, leading to the diagnosis of thrombotic microangiopathy. Later, we found that he had the constitutional abnormality XYY. XYY syndrome is a frequent congenital abnormality, and mental disorders and congenital abnormalities of kidney and liver are common manifestations. Considering his clinical course, it was interesting that complications were severe in the organs which are frequently involved in cases of XYY syndrome. These organs may have poor function or poor reserves and may be more vulnerable to endothelial damage caused by high-dose cytotoxic chemotherapy. Patients with XYY syndrome might have a high risk of transplantation-related mortality.


Related Articles

  • Plasmodium vivax causing pancytopenia after allogeneic blood stem cell transplantation in CML. Raina, V; Sharma, A; Gujral, S; Kumar, R // Bone Marrow Transplantation;7/15/98, Vol. 22 Issue 2, p205 

    A 20-year-old male patient with chronic myeloid leukemia (CML), in chronic phase, underwent allogeneic blood stem cell transplantation in August 1996. Engraftment was well documented in the marrow on day 19, but pancytopenia and mild splenomegaly continued. On day +70, the patient developed...

  • Extramedullary Relapse of the AML Transformed from MDS Following Auto-HSCT: A Case Report. Wang, Jin; Liu, Yu; Zhou, Xu; Li, Zheng; Li, Xiang; Xiao, Hualiang // Cell Biochemistry & Biophysics;Sep2014, Vol. 70 Issue 1, p409 

    The treatment for AML (Acute myeloid/myelogenous leukemia) transformed from MDS (myelodysplastic syndrome) is difficult and controversial clinically, especially in elder patients. In this case report, we diagnosed a 59-year-old female patient with AML-M2a transformed form MDS which might be...

  • Duodenal leishmaniasis after allogeneic hematopoietic SCT. Martínez-Losada, C; Martin, C; Cuenca, T; Torres, A // Bone Marrow Transplantation;Apr2013, Vol. 48 Issue 4, p614 

    The article describes a case of visceral leishmaniasis with duodenal involvement in a 49-year-old gypsy woman from Romania six months after allogeneic umbilical cord blood (UCB) stem cell transplantation for the treatment of acute myeloid leukemia with complex karyotype. It relates the outcome...

  • Recurrence of lymphoid blast crisis over 20 years after successful sibling allo-SCT for CML: short lived complete cytogenetic response to imatinib. Irvine, D. A.; Shepherd, J. D. // Bone Marrow Transplantation;Aug2009, Vol. 44 Issue 4, p267 

    The article presents a case study of a 41-year-old woman that has a history of fatigue, bone pains, and fever. Blood analysis demonstrated that she has pancytopenia with circulating blasts while bone marrow morphology and cytochemistry suggested lymphoid blast crisis of chronic myeloid leukemia....

  • Miscellaneous. Fox, Christopher; Mead, Adam; Skoetz, Nicole // Current Medical Literature: Leukemia & Lymphoma;2010, Vol. 18 Issue 2, p54 

    The article presents comments on various research on leukemia and lymphoma. A study by L. Raparia et al explored the diagnostic approach to intraocular lymphoma. Another research focused on allogeneic stem cell transplantation in patients suffering from myelofibrosis. One study also detailed a...

  • INCIDENCE OF DIARRHEA BY Clostridium difficile IN HEMATOLOGIC PATIENTS AND HEMATOPOIETIC STEM CELL TRANSPLANTATION PATIENTS: RISK FACTORS FOR SEVERE FORMS AND DEATH. SPADÃO, Fernanda; GERHARDT, Juliana; GUIMARÃES, Thais; DULLEY, Frederico; de ALMEIDA JUNIOR, João Nóbrega; BATISTA, Marjorie Vieira; SHIKANAI-YASUDA, Maria Aparecida; LEVIN, Anna Sara; COSTA, Silvia Figueiredo // Revista do Instituto de Medicina Tropical de Sao Paulo;Jul/Aug2014, Vol. 56 Issue 4, p325 

    We describe the rate of incidence of Clostridium difficile-associated diarrhea (CDAD) in hematologic and patients undergone stem cell transplant (HSCT) at HC-FMUSP, from January 2007 to June 2011, using two denominators 1,000 patient and 1,000 days of neutropenia and the risk factors associated...

  • 1. Acute Leukemia.  // Bone Marrow Transplantation;3/2/2002 Supplement, Vol. 29 Issue 5, pS70 

    Bone Marrow Transplantation (2001) 29, Suppl. 2, S70–S79. DOI: 10.1038/sj/bmt/1703463

  • Citations and Clinicians' Notes: Chronic Leukaemia. Or, R; Shapira, MY; Resnick, I; Amar, A; Ackerstein, A; Samuel, S; Aker, M; Naparstek, E; Nagler, A; Slavin, S // Current Medical Literature: Leukemia & Lymphoma;2003, Vol. 11 Issue 3, p59 

    Presents information on chronic leukemia from citations and notes of clinicians. Discussion on nonmyeloablative allogeneic stem cell transplantation for the treatment of chronic myeloid leukemia in first chronic phase; Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid...

  • Avoiding gobbledygook. Cox, Flick // Journal of Perioperative Practice;Nov2006, Vol. 16 Issue 11, p515 

    The author relates her experience in having acute myeloid leukaemia (AML). She mentions that the treatment of AML consists of chemotherapy and a peripheral stem cell transplant which offers the best chance of disease-free survival. Conditioning therapy prior to her stem cell transplant consisted...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics