TITLE

A man with hereditary exostoses and high-grade non-Hodgkin's lymphoma of the bone

AUTHOR(S)
Neben, K.; Werner, M.; Bernd, L.; Ewerbeck, V.; Delling, G.; Ho, A. D.
PUB. DATE
November 2001
SOURCE
Annals of Hematology;Nov2001, Vol. 80 Issue 11, p682
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Multiple cartilaginous exostoses (MCE) is an autosomal dominant disorder that can lead to malignant transformation from exostoses to a secondary chondrosarcoma. We present a case report of a 52-year-old man with MCE who had a palpable mass at the left shoulder. At the site of the left proximal humerus, a cartilaginous exostosis was localized, suggesting that the tumor developed by a malignant transformation of an exostosis into a secondary chondrosarcoma. Interestingly, a biopsy showed a diffuse large B-cell lymphoma with Burkitt-like features. To our knowledge, the association of high-grade lymphoma and hereditary exostoses has not been described previously. This case demonstrates that a malignant tumor at the location of a cartilaginous exostosis is not necessarily a chondrosarcoma and that a biopsy is an essential part of the diagnostic work-up.
ACCESSION #
15684818

 

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