Animal Models of Alcoholic Liver Disease--Focus on the Intragastric Feeding Model

Nanji, Amin A.; French, Samuel W.
December 2003
Alcohol Research & Health;2003, Vol. 27 Issue 4, p325
Academic Journal
The use of animal models has contributed to greater understanding of how alcoholic liver disease (MD) develops, and of how the severity of liver injury is influenced by factors other than alcohol, such as nutrition, oxygen deprivation (as occurs with sleep apnea or smoking), and gene regulation. This article focuses on the use of one animal model in particular, the intra gastric feeding model in rats. This model allows scientists to rigorously control an animal's consumption of both alcohol and dietary nutrients and is providing important information on the mechanisms of injury of alcoholic liver disease. INSET: ALCOHOL USE, OXIDATIVE STRESS, AND LIVER DAMAGE.


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