TITLE

Blood Eosinophilia: A New Paradigm in Disease Classification, Diagnosis, and Treatment

AUTHOR(S)
Tefferi, Ayalew
PUB. DATE
January 2005
SOURCE
Mayo Clinic Proceedings;Jan2005, Vol. 80 Issue 1, p75
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Acquired blood eosinophilia is considered either a primary or a secondary phenomenon. Causes of secondary (ie, reactive) eosinophilia include tissue-invasive parasitosis, ailergic or inflammatory conditions, and malignancies in which eosinophils are not considered part of the neoplastic process. Primary eosinophilia is classified operationally into 2 categories: clonal and Idiopathic. Clonal eosinophilia stipulates the presence of either cytogenetic evidence or bone marrow histological evidence of an otherwise classified hematologic malignancy such as acute leukemia or a chronic myeloid disorder, idiopathic eosinophilia is a diagnosis of exclusion (ie. not secondary or clonal). Hypereosinophilic syndrome is a subcategory of idiopathic eosinophilia: diagnosis requires documentation of both sustained eosinophilia (absolute eosinophil count ⩽1500 cells/μL for at least 6 months) and target organ damage (eg, involvement of the heart, lung, skin, or nerve tissue). Genetic mutations involving the platelet-derived growth factor receptor genes (PDGFR-α and PDGFR-β) have been pathogenetically linked to clonal eosinophilia, and their presence predicts treatment response to imatinib. Accordingly, cytogenetic and/or molecular investigations for the presence of an imatinibsensitive molecular target should accompany current evaluation for primary eosinophilia. In the absence of such a drug target, specific treatment is dictated by the underlying hematologic malignancy in cases of clonal eosinophilia; however, the initial treatment of choice for symptomatic patients with hypereosinophilic syndrome is prednisone and/or interferon alfa.
ACCESSION #
15661487

 

Related Articles

  • Hydroxychloroquine-induced DRESS syndrome. Volpe, Alessandro; Marchetta, Antonio; Caramaschi, Paola; Biasi, Domenico; Bambara, Lisa Maria; Arcaro, Guido // Clinical Rheumatology;Apr2008, Vol. 27 Issue 4, p537 

    The authors describe the first case of drug rash with eosinophilia and systemic symptoms syndrome caused by hydroxychloroquine treatment in a male patient affected by seronegative arthritis.

  • Papuloerythroderma of Ofuji - a case report. Iffat Hassan; Mashkoor Ahmad; Qazi Manaan; Sajjad Hussain; Qazi Masood // Journal of Pakistan Association of Dermatologists;Jan-Mar2013, Vol. 23 Issue 1, p103 

    Papuloerythroderma of Ofuji is an uncommon skin condition seen in elderly patients characterized by pruritic eruption of infiltrating papules with sparing of large folds of skin. Very few cases have been reported in the literature and the frequent association of this rare entity with laboratory...

  • Mesenteric Venous Thrombosis With Bowel Infarction and Hyperhomocysteinemia Due to Homozygous Methylenetetrahydrofolate Reductase C677T Genotype. Hotoleanu, Cristina; Andercou, Octavian; Andercou, Aurel // Vascular & Endovascular Surgery;Oct/Nov2008, Vol. 42 Issue 5, p477 

    The case of a 30-year-old man with bowel infarction due to mesenteric venous thrombosis and multiple risk factors, including mild hyperhomocysteinemia due to methylenetetrahydrofolate reductase C677T polymorphism and recent abdominal surgery, is reported. His clinical manifestation consisted of...

  • Evaluation of Patients with Leukocytosis. RILEY, LYRAD K.; RUPERT, JEDDA // American Family Physician;12/1/2015, Vol. 92 Issue 11, p1004 

    An elevated white blood cell count has many potential etiologies, including malignant and nonmalignant causes. It is important to use age- and pregnancy-specific normal ranges for the white blood cell count. A repeat complete blood count with peripheral smear may provide helpful information,...

  • Five years since the discovery of FIP1L1-PDGFRA: what we have learned about the fusion and other molecularly defined eosinophilias. Gotlib, J.; Cools, J. // Leukemia (08876924);Nov2008, Vol. 22 Issue 11, p1999 

    The year 2008 marks the fifth anniversary since the publication which identified the FIP1L1-PDGFRA fusion gene in patients with idiopathic hypereosinophilia. With the benefit of time, a more comprehensive picture has emerged regarding several characteristics of the fusion, including its...

  • Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland: Description of a case and review of the literature. Kanat, Özkan; Evrensel, Türkkan; Tolunay, Šahsine; Demiray, Mutlu; Gönüllü, Güzin; Kurt, Ender; Manavoglu, Osman // Turkish Journal of Cancer;Jul2004, Vol. 34 Issue 3, p122 

    Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is a recently recognized malignant neoplasm of the thyroid gland associated with Hashimoto's thyroiditis. At present, only 24 cases of SMECE have been reported in the literature. Although most of these patients had a relatively...

  • Is leukocytosis a predictor of mortality in severe pertussis infection? Pierce, Christine; Klein, Nigel; Peters, Mark // Intensive Care Medicine;Oct2000, Vol. 26 Issue 10, p1512 

    Bordetella pertussis causing severe respiratory failure in infants that is unresponsive to treatment is well described. Pulmonary hypertension is a prominent feature of such cases. In this series of 13 critically ill infants with B. pertussis, hyperleukocytosis (>100×109/l) was an...

  • Effect of Clitoria ternatea seeds extract on milk-induced leucocytosis and eosinophilia in mice. Taur, Dnyaneshwar J.; Patil, Ravindra Y. // Journal of Pharmacy Research;Dec2009, Vol. 2 Issue 12, p1839 

    Clitoria ternatea L. (Family: Fabaceae) is a perimial twing herb. The roots have a sharp bitter taste and cooling, laxative, diuretic, anthelmintic, anti-inflammatory properties; they are useful in severe bronchitis, asthma and fever. Stem and flower are recommended for treatment of snake bites....

  • enzymes the Catalysts of our Life Force. French, Roger // New Vegetarian & Natural Health;Winter2006, p12 

    The article offers information about digestive leukocytosis, a dramatic disease in the level of activity of white blood cells in the blood after undigested cooked food passes from the intestine into the bloodstream. This disease was first explained by Swiss doctor Paul Kautchakoff during the...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics